ArticleFrontiers in cellular neuroscience2012
Co-Release of GABA Does Not Occur at Glycinergic Synapses onto Lumbar Motoneurons in Juvenile Mice.
Article in Frontiers in cellular neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Heterogeneous Signaling at GABA and Glycine Co-releasing Terminals.Frontiers in synaptic neuroscience · 2018Article
- Segregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse.Scientific reports · 2017Article
- Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia.The Journal of biological chemistry · 2016Article
- Synaptic Connectivity between Renshaw Cells and Motoneurons in the Recurrent Inhibitory Circuit of the Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Not GABA but glycine mediates segmental, propriospinal, and bulbospinal postsynaptic inhibition in adult mouse spinal forelimb motor neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The recurrent case for the Renshaw cell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Principles of interneuron development learned from Renshaw cells and the motoneuron recurrent inhibitory circuit.Annals of the New York Academy of Sciences · 2013Review
- Genetic deficiency of GABA differentially regulates respiratory and non-respiratory motor neuron development.PloS one · 2013Article
- Building up the inhibitory synapse.Frontiers in cellular neuroscience · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The fast inhibitory neurotransmitters glycine and GABA are co-localized in synaptic terminals of inhibitory interneurons in the spinal cord and co-released onto lumbar motoneurons in neonatal rats. We performed whole-cell voltage-clamp experiments on spinal cord preparations obtained from juvenile (P8-14) mice to determine whether inhibitory currents exhibited GABAergic components in motoneurons of animals of weight-bearing age. Subsequently we established whether or not GABA is co-released at glycinergic synapses onto motoneurons by determining if it conferred modulatory effects on the kinetics of glycinergic currents. Exponential fitting analysis showed that evoked and miniature inhibitory post-synaptic currents (IPSCs) were best-fitted with a single decay time constant. Responses recorded from connected interneuron-motoneuron pairs showed no effect of a benzodiazepine or a GABA(A) receptor antagonist. Similarly IPSCs evoked by extracellular stimulation and miniature IPSCs were not affected by either agent, indicating the absence of co-detection. Experimental manipulation of the relative content of pre-synaptic GABA and glycine conferred no effect on post-synaptic responses. It is thus unlikely that GABA is co-released in biologically relevant amounts at glycinergic synapses onto lumbar motoneurons in mice of this age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.