ArticleJournal of immunology (Baltimore, Md. : 1950)2012
Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- The role of immunoglobulin E in non-atopic disorders.Frontiers in immunology · 2025Review
- Immunotherapy with biodegradable nanoparticles encapsulating the oligosaccharide galactose-alpha-1,3-galactose enhance immune tolerance against alpha-gal sensitization in a murine model of alpha-gal syndrome.Frontiers in allergy · 2024Article
- The Potential Nexus between Helminths and SARS-CoV-2 Infection: A Literature Review.Journal of immunology research · 2023Review
- Human filariasis-contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model.Parasitology research · 2021Review
- IL-10 as a Th2 Cytokine: Differences Between Mice and Humans.Journal of immunology (Baltimore, Md. : 1950) · 2021Review
- Diverse innate stimuli activate basophils through pathways involving Syk and IκB kinases.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The immune response of inbred laboratory mice to Litomosoides sigmodontis: A route to discovery in myeloid cell biology.Parasite immunology · 2020Review
- The Gastrointestinal HelminthFrontiers in immunology · 2020Article
- Cutaneous Exposure to Clinically Relevant Lone Star Ticks Promotes IgE Production and Hypersensitivity through CD4Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Allergen presensitization drives an eosinophil-dependent arrest in lung-specific helminth development.The Journal of clinical investigation · 2019Article
- Fasciola hepatica GST downregulates NF-κB pathway effectors and inflammatory cytokines while promoting survival in a mouse septic shock model.Scientific reports · 2019Article
- Immunoglobulin E-Mediated Autoimmunity.Frontiers in immunology · 2018Review
- Helminth parasites and immune regulation.F1000Research · 2018Review
- Toxoplasma gondii tachyzoite-extract acts as a potent immunomodulator against allergic sensitization and airway inflammation.Scientific reports · 2017Article
- The role of rare innate immune cells in Type 2 immune activation against parasitic helminths.Parasitology · 2017Review
- Human Helminths and Allergic Disease: The Hygiene Hypothesis and Beyond.The American journal of tropical medicine and hygiene · 2016Review
- Role of basophils in protective immunity to parasitic infections.Seminars in immunopathology · 2016Review
- Role in Allergic Diseases of Immunological Cross-Reactivity between Allergens and Homologues of Parasite Proteins.Critical reviews in immunology · 2016Review
- Particularities of allergy in the Tropics.The World Allergy Organization journal · 2016Review
- Ten Weeks of Infection with a Tissue-Invasive Helminth Protects against Local Immune Complex-Mediated Inflammation, but Not Cutaneous Type I Hypersensitivity, in Previously Sensitized Mice.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Basophils play a key role in the development and effector phases of type 2 immune responses in both allergic diseases and helminth infections. This study shows that basophils become less responsive to IgE-mediated stimulation when mice are chronically infected with Litomosoides sigmodontis, a filarial nematode, and Schistosoma mansoni, a blood fluke. Although excretory/secretory products from microfilariae of L. sigmodontis suppressed basophils in vitro, transfer of microfilariae into mice did not result in basophil suppression. Rather, reduced basophil responsiveness, which required the presence of live helminths, was found to be dependent on host IL-10 and was accompanied by decreases in key IgE signaling molecules known to be downregulated by IL-10. Given the importance of basophils in the development of type 2 immune responses, these findings help explain the mechanism by which helminths protect against allergy and may have broad implications for understanding how helminth infections alter other disease states in people.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.