ArticleScience (New York, N.Y.)2012
Hierarchical genetic organization of human cortical surface area.
Article in Science (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
172 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes.Cerebral cortex (New York, N.Y. : 1991) · 2020Pooled it
- Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.Brain imaging and behavior · 2013Pooled it
- Go/No Go task performance predicts cortical thickness in the caudal inferior frontal gyrus in young adults with and without ADHD.Brain imaging and behavior · 2016Trial
- Genetic topography of brain morphology.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Mapping Focal and Generalized Effects of Common Genetic Variants on Human Brain Structure.bioRxiv : the preprint server for biology · 2026Article
- Surface expansion regionalization of the hippocampus in early brain development.Developmental cognitive neuroscience · 2026Article
- Brain morphometry, stimulation charge, and seizure duration in electroconvulsive therapy.Molecular psychiatry · 2026Article
- The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology.Communications biology · 2026Article
- Cerebral cortical structures linked to intelligence.bioRxiv : the preprint server for biology · 2025Article
- Spatiotemporal Patterns in Cortical Development: Age, Puberty, and Individual Variability from 9 to 13 Years of Age.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cognitive and Global Morphometry Trajectories as Predictors of Youth Persistent Distressing Psychotic-Like Experiences.Nature. Mental health · 2025Article
- Genetic effect on working memory activation pattern and structural properties of cortical gray matter.Scientific reports · 2025Article
- A genetically informed brain atlas for enhancing brain imaging genomics.Nature communications · 2025Article
- Topographic Axes of Wiring Space Converge to Genetic Topography in Shaping the Human Cortical Layout.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A Site-Wise Reliability Analysis of the ABCD Diffusion Fractional Anisotropy and Cortical Thickness: Impact of Scanner Platforms.Human brain mapping · 2024Article
- Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture.Translational psychiatry · 2024Article
- A 3D approach to understanding heterogeneity in early developing autisms.Molecular autism · 2024Article
- Revealing Fine-grained Genetically Informed Cortical Parcellation Maps of Neonates Based on Multi-view Spectral Clustering.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
112 more citing papers are in PubMed but not listed here.
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17 authors.
Funding
Abstract
Surface area of the cerebral cortex is a highly heritable trait, yet little is known about genetic influences on regional cortical differentiation in humans. Using a data-driven, fuzzy clustering technique with magnetic resonance imaging data from 406 twins, we parceled cortical surface area into genetic subdivisions, creating a human brain atlas based solely on genetically informative data. Boundaries of the genetic divisions corresponded largely to meaningful structural and functional regions; however, the divisions represented previously undescribed phenotypes different from conventional (non-genetically based) parcellation systems. The genetic organization of cortical area was hierarchical, modular, and predominantly bilaterally symmetric across hemispheres. We also found that the results were consistent with human-specific regions being subdivisions of previously described, genetically based lobar regionalization patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.