Evidence map›Paper›PMID 22461404›Full record

ArticleHuman brain mapping2013

Connectomics signatures of prenatal cocaine exposure affected adolescent brains.

Kaiming Li, Dajiang Zhu, Lei Guo, Zhihao Li, Mary Ellen Lynch, Claire Coles, Xiaoping Hu, Tianming Liu

Open access · greenAbstract read
In one paragraph

Article in Human brain mapping, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Bayesian Inference for Functional Dynamics Exploring in fMRI Data.Computational and mathematical methods in medicine · 2016
    Review
  9. Article
  10. Article
  11. GENETIC ANALYSIS OF STRUCTURAL BRAIN CONNECTIVITY USING DICCCOL MODELS OF DIFFUSION MRI IN 522 TWINS.Proceedings. IEEE International Symposium on Biomedical Imaging · 2015
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Imaging brain plasticity after trauma.Neural regeneration research · 2014
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kaiming LiDepartment of Automatic Control, School of Automation, Northwestern Polytechnic University, Xi'an, China; Department of Computer Science and Bioimaging Research Center, The University of Georgia, Athens, Georgia.
Dajiang Zhu
Lei Guo
Zhihao Li
Mary Ellen Lynch
Claire Coles
Xiaoping Hu
Tianming Liu
Emory University · USUniversity of Georgia · US

Funding

Exercise & Overweight Children's CognitionR01HL087923 · NHLBI · AUGUSTA UNIVERSITY · PI DAVIS, CATHERINE LUCY, MCDOWELL, JENNIFER E · 2008 to 2012
$5.2M
Developmental Effects of Prenatal Cocaine ExposureR01DA017795 · NIDA · EMORY UNIVERSITY · PI HU, XIAOPING P · 2004 to 2008
$2.5M
Assessing Large-scale Connectivities in Prenatal Cocaine Exposure Affected BrainsR01DA033393 · NIDA · UNIVERSITY OF GEORGIA · PI HU, XIAOPING P, LIU, TIANMING · 2012 to 2016
$1.6M
Assessing Large-scale Brain Connectivities in Mild Cognitive ImpairmentR01AG042599 · NIA · UNIVERSITY OF GEORGIA · PI LIU, TIANMING · 2013 to 2017
$1.4M
Computer Aided Diagnosis and Followup of Alzheimer's DiseaseK01EB006878 · NIBIB · UNIVERSITY OF GEORGIA · PI LIU, TIANMING · 2007 to 2010
$477k
NHLBI NIH HHS R01 HL087923NHLBI NIH HHS R01 HL087923-03S2NIA NIH HHS R01 AG042599NIBIB NIH HHS EB 006878NIBIB NIH HHS K01 EB006878NIDA NIH HHS R01 DA017795NIDA NIH HHS R01 DA033393NIDA NIH HHS R01 DA17795
6 · The paper itself

Abstract

Recent in vivo neuroimaging studies revealed that several brain networks are altered in prenatal cocaine exposure (PCE) affected adolescent brains. However, due to a lack of dense and corresponding cortical landmarks across individuals, the systematical alterations of functional connectivities in large-scale brain networks and the alteration of structural brain architecture in PCE affected brain are largely unknown. In this article, we adopted a newly developed data-driven strategy to build a large set of cortical landmarks that are consistent and corresponding across PCE adolescents and their matched controls. Based on these landmarks, we constructed large-scale functional connectomes and applied the well-established approaches of deriving genomics signatures in genome-wide gene expression studies to discover functional connectomics signatures for the characterization of PCE adolescent brains. Results derived from experimental data demonstrated that 10 structurally disrupted landmarks were identified in PCE, and more importantly, the discovered informative functional connectomics signatures among consistent landmarks distinctively differentiate PCE brains from their matched controls.

Indexed as

AdolescentConnectomeAlgorithmsAnatomic LandmarksBrainCase-Control StudiesCocaineCocaine-Related DisordersFemaleFollow-Up StudiesGene Expression ProfilingHumansMaleMaternal-Fetal ExchangeNerve Tissue ProteinsNeuroimagingCocaineNerve Tissue Proteinsconnectomediffusion tensor imagingresting state fMRI

Identifiers

PMID22461404
PMCPMC3954601
OpenAlexW1933931696

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.