ArticleAmerican journal of respiratory and critical care medicine2012
Genetic variation in vascular endothelial growth factor-a and lung function.
Article in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifieseLife · 2023Pooled it
- Development of the Respiratory System During Adolescence.Advances in experimental medicine and biology · 2026Review
- Targeted anti-cancer therapy: Co-delivery of VEGF siRNA and Phenethyl isothiocyanate (PEITC) via cRGD-modified lipid nanoparticles for enhanced anti-angiogenic efficacy.Asian journal of pharmaceutical sciences · 2024Article
- Does Chronic Obstructive Pulmonary Disease Originate from Different Cell Types?American journal of respiratory cell and molecular biology · 2023Article
- Review
- Diabetic endothelial microangiopathy and pulmonary dysfunction.Frontiers in endocrinology · 2023Review
- Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates.American journal of respiratory and critical care medicine · 2022Article
- How VEGF-A and its splice variants affect breast cancer development - clinical implications.Cellular oncology (Dordrecht, Netherlands) · 2022Review
- Genetics of Asthma and Allergic Diseases.Handbook of experimental pharmacology · 2022Article
- Role ofBiomedicines · 2021Article
- Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma.Allergy, asthma & immunology research · 2019Review
- Sevoflurane Prevents Airway Remodeling via Downregulation of VEGF and TGF-β1 in Mice with OVA-Induced Chronic Airway Inflammation.Inflammation · 2019Article
- Early Lung Function and Future Asthma.Frontiers in pediatrics · 2019Review
- The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD).Respiratory research · 2017Review
- Polymorphisms in VEGF-A are associated with COPD risk in the Chinese population from Hainan province.Journal of genetics · 2016Article
- Role of HIF1A, VEGFA and VEGFR2 SNPs in the Susceptibility and Progression of COPD in a Spanish Population.PloS one · 2016Article
- Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years.The Journal of allergy and clinical immunology · 2015Article
- Aryl hydrocarbon receptor agonists upregulate VEGF secretion from bronchial epithelial cells.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Trajectories of lung function during childhood.American journal of respiratory and critical care medicine · 2014Article
- Vascular endothelial growth factor as a key inducer of angiogenesis in the asthmatic airways.Current allergy and asthma reports · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
Abstract
rationaleGiven the role of vascular endothelial growth factor (VEGF) in lung development, we hypothesized that polymorphisms in VEGF-A may be associated with lung function.
objectivesThe current study was designed to assess the role of genetic variants in VEGF-A as determinants of airway function from infancy through early adulthood.
methodsAssociation between five single-nucleotide polymorphisms (SNPs) in VEGF-A and lung function were assessed longitudinally in two unselected birth cohorts and cross-sectionally among infants. Replication with two SNPs was conducted in adults and children with asthma. We investigated the functionality of the SNP most consistently associated with lung function (rs3025028) using Western blotting to measure the ratio of plasma VEGF-A(165b)/panVEGF-A(165) among homozygotes. MEASUREMENTS AND MAIN
resultsIn two populations in infancy, C-allele homozygotes of rs3025028 had significantly higher VmaxFRC, forced expiratory flow(50), and forced expiratory flow(25-75) compared with other genotype groups. Among preschool children (age 3 yr), C allele of rs3025028 was associated with significantly higher specific airway conductance, with similar findings observed for lung function in school-age children. For FEV(1)/FVC ratio similar findings were observed among adolescents and young adults (birth cohort), and then replicated in adults and schoolchildren with asthma (cross-sectional studies). For rs3025038, plasma VEGF-A(165b)/panVEGF-A(165) was significantly higher among CC versus GG homozygotes (P ≤ 0.02) at birth, in school-age children, and in adults.
conclusionsWe report significant associations between VEGF-A SNP rs3025028 and parameters of airway function measured throughout childhood, with the effect persisting into adulthood. We propose that the mechanism may be mediated through the ratios of active and inhibitory isoforms of VEGF-A(165), which may be determined by alternative splicing.
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Registered trials
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