ArticleAmerican journal of physiology. Renal physiology2012
Mechanisms of angiotensin II-enhanced connecting tubule glomerular feedback.
Article in American journal of physiology. Renal physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Luminal flow in the connecting tubule induces afferent arteriole vasodilation.Clinical and experimental nephrology · 2025Article
- Luminal Flow in the Connecting Tubule induces Afferent Arteriole Vasodilation.bioRxiv : the preprint server for biology · 2024Article
- Epithelial N-methyl-D-aspartate (NMDA) receptors mediate renal vasodilation by affecting kidney autoregulation.bioRxiv : the preprint server for biology · 2023Article
- Endocrine Effects of Simulated Complete and Partial Aortic Occlusion in a Swine Model of Hemorrhagic Shock.Military medicine · 2019Article
- A Novel Mechanism of Renal Microcirculation Regulation: Connecting Tubule-Glomerular Feedback.Current hypertension reports · 2019Review
- Effect of salt intake on afferent arteriolar dilatation: role of connecting tubule glomerular feedback (CTGF).American journal of physiology. Renal physiology · 2017Article
- Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet.World journal of nephrology · 2017Article
- Mechanisms of connecting tubule glomerular feedback enhancement by aldosterone.American journal of physiology. Renal physiology · 2016Article
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Aldosterone sensitizes connecting tubule glomerular feedback via the aldosterone receptor GPR30.American journal of physiology. Renal physiology · 2014Article
- Intrarenal renin-angiotensin system in regulation of glomerular function.Current opinion in nephrology and hypertension · 2014Review
- Oxidative stress in hypertension: role of the kidney.Antioxidants & redox signaling · 2014Review
- Prostaglandin E2 mediates connecting tubule glomerular feedback.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Cell signaling through protein kinase C oxidation and activation.International journal of molecular sciences · 2012Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Increasing Na delivery to the connecting tubule (CNT) causes afferent arteriole (Af-Art) dilation, a process we call CNT glomerular feedback (CTGF). Angiotensin II (ANG II) in the CNT lumen enhances CTGF via PKC. We hypothesized that luminal ANG II stimulates CTGF via activation of protein kinase C (PKC), NADPH oxidase 2 (NOX2), and enhanced production of superoxide (O(2)(-)). Rabbit Af-Arts and adherent CNTs were microdissected and microperfused in vitro. Dilation of the Af-Art was induced by increasing luminal CNT NaCl from 0 to 5, 10, 30, 45, and 80 mM, and the concentration of NaCl that elicited a half-maximal response (EC(50)) was calculated. Compared with vehicle, adding ANG II (10(-9) M) to the CNT lumen reduced EC(50) from 37 ± 3 to 14 ± 1 mM (P < 0.001), indicating ANG II potentiates CTGF. In the presence of ANG II, the O(2)(-) scavenger tempol (10(-4) M) increased EC(50) from 20 ± 4 to 41 ± 3 mM (P < 0.01), the NOX inhibitor apocynin (10(-5) M) increased EC(50) from 17 ± 2 to 39 ± 4 mM (P < 0.01), and the specific NOX2 inhibitor gp91ds-tat (10(-5) M) increased EC(50) from 19 ± 2 to 34 ± 2 mM (P < 0.01). However, tempol, apocynin, and gp91ds-tat had no effect on CTGF in the absence of ANG II. Compared with vehicle, the PKC activator PMA (2 × 10(-7) M) decreased EC(50) from 35 ± 2 to 14 ± 1 (P < 0.001). In the presence of PMA, tempol increased EC(50) from 14 ± 2 to 35 ± 2 mM (P < 0.01). We conclude the PKC/NOX2/O(2)(-) pathway mediates the enhancement of CTGF by luminal ANG II but it does not participate in CTGF in the absence of ANG II.
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