ArticleClinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases2007
Calcitonin and calcitonin receptors.
Article in Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 74 citations in OpenAlex.
- Review
- Biosynthesis, Chemical Synthesis, and Pharmacological Evaluation of Lyngbyapeptin A as a GPCR Antagonist of Motilin, Cannabinoid, and Amylin Receptors.Journal of natural products · 2025Article
- Development of Petrelintide: a Potent, Stable, Long-Acting Human Amylin Analogue.Journal of medicinal chemistry · 2025Article
- Neonatal Severe Hyperparathyroidism: Anaesthetic Considerations for Removal of Pea-size Glands in Children.Turkish journal of anaesthesiology and reanimation · 2025Article
- Article
- CALCR interaction with ANTXR1 drives gastric tumor growth and metastasis via AKT signaling pathway.Scientific reports · 2025Article
- Computational insights into the aggregation mechanism of human calcitonin.International journal of biological macromolecules · 2025Article
- Role of CALCR expression in liver cancer: Implications for the immunotherapy response.Molecular medicine reports · 2025Article
- miR-148b-5p regulates hypercalciuria and calcium-containing nephrolithiasis.Cellular and molecular life sciences : CMLS · 2024Article
- We need to talk-how muscle stem cells communicate.Frontiers in cell and developmental biology · 2024Review
- Peptide Drugs: Current Status and it's Applications in the Treatment of Various Diseases.Current drug research reviews · 2024Review
- Calcitonin receptor signaling in nucleus accumbens D1R- and D2R-expressing medium spiny neurons bidirectionally alters opioid taking in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Polymorphisms in Genes Encoding VDR, CALCR and Antioxidant Enzymes as Predictors of Bone Tissue Condition in Young, Healthy Men.International journal of molecular sciences · 2023Article
- Association of TRPV5, CASR, and CALCR genetic variants with kidney stone disease susceptibility in Egyptians through main effects and gene-gene interactions.Urolithiasis · 2022Article
- Effect of Regulator of G Protein Signaling Proteins on Bone.Frontiers in endocrinology · 2022Review
- Calcitonin: current concepts and differential diagnosis.Therapeutic advances in endocrinology and metabolism · 2022Review
- Use of Calcitonin for Hypercalcemia in a Premature Neonate With Congenital Mesoblastic Nephroma.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- The effect of salmon calcitonin against glutamate-induced cytotoxicity in the C6 cell line and the roles the inflammatory and nitric oxide pathways play.Metabolic brain disease · 2021Article
- Fluid intake, what's dopamine got to do with it?Physiology & behavior · 2021Article
- New aspects of endocrine control of atrial fibrillation and possibilities for clinical translation.Cardiovascular research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcitonin (CT) is a polypeptide hormone with 32 aminoacids syntetized primarily by the thyroid.Several evidences support the existence of nonthyroidal CT like peptide. The CT gene transcript also encodes a distinct peptide known as calcitonin gene related peptide (CGRP) which is a potent vasodilator and responsible for the stimulation of the glomerular filtration rate. In addition, a 37 aminoacid peptide amylin has been originally isolated by pancreatic β-cells. Amylin is able to inhibit insulin secretion, glucose transport into the skeletal musculature and gluconeogenesis. It is also able to inhibit gastric emptying. In the kidney it is able to modulate Calcium (Ca(2+)) excretion and increases renin activity. Finally, high affinity amylin receptors have been identified in the brain of the rat. The calcitonin receptor (CTR) is a member of a subfamily of the seven-transmembrane domain G-protein coupled receptor super family that includes several peptides. Members of this family have a similar structure with other seven-membrane-spanning domain G-protein coupled receptors.The genetic contribution to osteoporosis susceptibility is well documented and many studies demonstrated that genetic factors play important roles in the regulation of bone metabolism. Restriction Fragment Length Polymorphisms (RFLPs) for the CTR gene have been described in the literature with a positive association with the lumbar bone mineral density (BMD), femoral neck BMD and with a lower incidence of vertebral fractures.
Identifiers
22461211PMC2781237W1499864289What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.