ArticleJournal of molecular histology2012
Expression of A20 is reduced in pancreatic cancer tissues.
Article in Journal of molecular histology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- The Role of A20 in Cancer: Friend or Foe?Cells · 2025Review
- Differential expression of the ubiquitin-editing enzyme A20 in gastric biopsies indicates the severity of disease.Histochemistry and cell biology · 2024Article
- Clinical and Basic Evaluation of the Effects of Upregulated TNFAIP3 Expression on Colorectal Cancer.Disease markers · 2022Article
- The prognostic evaluation of CA19-9, D-dimer and TNFAIP3/A20 in patients with pancreatic ductal adenocarcinoma.Medicine · 2021Observational
- A20 inhibits the motility of HCC cells induced by TNF-α.Oncotarget · 2016Article
- A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression.Molecular cancer · 2015Article
- Ursolic acid from Trailliaedoxa gracilis induces apoptosis in medullary thyroid carcinoma cells.Molecular medicine reports · 2015Article
- Overexpression of MALT1-A20-NF-κB in adult B-cell acute lymphoblastic leukemia.Cancer cell international · 2015Article
- Functional effect of polymorphisms in the promoter of TNFAIP3 (A20) in acute pancreatitis in the Han Chinese population.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A20 protein plays essential roles in tumorigenesis, but its value for diagnosis of pancreatic cancer remains unclear. Our aim was to determine whether A20 is a potential biomarker for the diagnosis of pancreatic cancer. The pancreatic cancer tissue microarray contained pancreatic cancer tissues (n = 40) and normal tissues (n = 10) was immunohistochemically assessed for A20 expression. The association of A20 expression with the tumor grade, lymph node metastasis, age and gender in pancreatic cancer patients were estimated by ANOVA. Stronger staining of A20 was observed in the normal tissues compared with that in the pancreatic cancer tissues (P = 0.003). ANOVA analysis showed that the A20 expression was not deeply associated with tumor grade, gender, age or TNM stages. The results implied that low A20 expression is significantly associated with the pancreatic cancer behavior, but is not the sole determinant of pancreatic cancer progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.