ReviewPediatric nephrology (Berlin, Germany)2013
Genetics of pediatric renal tumors.
Review in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 65 citations in OpenAlex.
- A rare coincidence of intrarenal Wilms tumor with spina bifida: a case report and review of the literature.International journal of surgery case reports · 2025Article
- Predictors of Surgical Complications and Survival in Pediatric Wilms' Tumor: A 20-Year Retrospective Study from Two Thai Centers.Current oncology (Toronto, Ont.) · 2025Article
- Contrast-enhanced ultrasound for differentiating benign from malignant focal solid renal lesions in pediatric patients.Scientific reports · 2024Article
- Report and follow-up on two new patients with congenital mesoblastic nephroma.Italian journal of pediatrics · 2023Article
- [Tumor predisposition syndromes and nephroblastoma : Early diagnosis with imaging].Radiologie (Heidelberg, Germany) · 2022Review
- Bilateral Renal Tumors in Children: The First 5 Years' Experience of National Centralization in The Netherlands and a Narrative Review of the Literature.Journal of clinical medicine · 2021Article
- Genetic Polymorphisms of theJournal of kidney cancer and VHL · 2021Article
- An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.Nature communications · 2020Article
- Clear cell sarcoma of the kidney in children: a clinopathologic analysis of three cases.International journal of clinical and experimental pathology · 2020Article
- Genetic and epigenetic analyses guided by high resolution whole-genome SNP array reveals a possible role ofOncotarget · 2018Article
- WT1 Alternative Splicing: Role of Its Isoforms in Neuroblastoma.Journal of molecular neuroscience : MN · 2017Review
- Genomic imbalances pinpoint potential oncogenes and tumor suppressors in Wilms tumors.Molecular cytogenetics · 2016Article
- Malignant rhabdoid tumor of the small intestine in adults: a brief review of the literature and report of a case.Surgery today · 2015Review
- Clinical and molecular characterization of patients with heterozygous mutations in wilms tumor suppressor gene 1.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
- High dose therapy for recurrent Wilms' tumor.Translational pediatrics · 2014Article
- Is Wilms tumor a candidate neoplasia for treatment with WNT/β-catenin pathway modulators?--A report from the renal tumors biology-driven drug development workshop.Molecular cancer therapeutics · 2013Review
- Renal Tumors of Childhood: Radiologic-Pathologic Correlation Part 2. The 2nd Decade: From the Radiologic Pathology Archives.Radiographics : a review publication of the Radiological Society of North America, IncReview
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wilms tumor (WT) accounts for approximately 95 % of all pediatric renal tumors, with a peak incidence between 2 and 3 years of age. It occurs in sporadic and congenital forms, the latter often occurring before 1 year of age. Incidence declines with age, and WT rarely is observed in adults. WT is an embryonal tumor of the kidney caused by aberrant proliferation of early metanephric kidney cells. It can arise from more than one developmental error and therefore several subtypes can be defined. WT1, a zinc-finger transcription factor, was identified as the first WT gene. Other genes frequently altered somatically in subsets of WT are CTNNB1 and WTX; both genes influence the Wnt signalling pathway. Imprinting alterations of genes in 11p15 are also observed in a subset of WTs. Other pediatric renal tumors occur less often, e.g. malignant rhabdoid tumor of the kidney, clear-cell sarcoma, desmoplastic small-round-cell tumors, congenital mesoblastic nephroma, renal cell carcinoma of childhood, renal primitive neuroectodermal tumors, renal medullary carcinoma, and synovial sarcoma of the kidney. In most of these, characteristic genetic alterations have been identified that help in the unequivocal diagnosis of these childhood renal cancers that are often difficult to distinguish.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.