ArticleCurrent microbiology2012
Extracellular proteins from Lactobacillus plantarum BMCM12 prevent adhesion of enteropathogens to mucin.
Article in Current microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
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- Lactobacillus-derived components for inhibiting biofilm formation in the food industry.World journal of microbiology & biotechnology · 2024Review
- Screening ofFoods (Basel, Switzerland) · 2023Article
- Antibiofilm, AntiAdhesive and Anti-Invasive Activities of Bacterial Lysates Extracted fromFoods (Basel, Switzerland) · 2022Article
- Effects of Spore-Displayed p75 Protein fromMicroorganisms · 2022Article
- Postbiotics Enhance NK Cell Activation in Stress-Induced Mice through Gut Microbiome Regulation.Journal of microbiology and biotechnology · 2022Article
- Isolation, identification, and impact on intestinal barrier integrity ofBioscience of microbiota, food and health · 2021Article
- Influence of Heterologously Expressed azurin from Pseudomonas aeruginosa on the Adhesion and Invasion of Pathogenic Bacteria to the Caco-2 Cell Line.Probiotics and antimicrobial proteins · 2020Article
- Surface components and metabolites of probiotics for regulation of intestinal epithelial barrier.Microbial cell factories · 2020Review
- Regional characteristics ofBioscience of microbiota, food and health · 2019Article
- Diet, microbiome, and the intestinal epithelium: an essential triumvirate?BioMed research international · 2013Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to study the interference of the extracellular proteins produced by Lactobacillus plantarum BMCM12 with the adhesion of some well-known gut pathogens. The extracellular proteins secreted by L. plantarum BMCM12 in MRS broth were precipitated, resolved by SDS-PAGE, and identified by tandem mass spectrometry. Discordances between the observed and the theoretical molecular masses of several proteins suggested the presence of protein glycosylation, corroborated with specific glycoprotein staining after protein de-glycosylation using trifluoromethanesulfonic acid. Experiments of exclusion, competition, or prevention of the pathogen adhesion to mucin were performed using BMCM12 extracellular proteins, using Escherichia coli LMG2092 and Salmonella enterica subsp. enterica LMG15860. Extracellular proteins from BMCM12 reduced significantly the adhesion of the pathogens when they were added prior to adhesion assays. These proteins play thus important roles in preventing pathogen adhesion to the mucin layer.
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Registered trials
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