ArticleProceedings of the National Academy of Sciences of the United States of America2012
Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 3 of them syntheses that pooled it.
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Who cites it
135 citing papers in PubMed, 3 syntheses or guidelines pooled it, 251 citations in OpenAlex.
- Piperonyl butoxide (PBO) combined with pyrethroids in insecticide-treated nets to prevent malaria in Africa.The Cochrane database of systematic reviews · 2021Pooled it
- Piperonyl butoxide (PBO) combined with pyrethroids in insecticide-treated nets to prevent malaria in Africa.The Cochrane database of systematic reviews · 2018Pooled it
- The impact of pyrethroid resistance on the efficacy of insecticide-treated bed nets against African anopheline mosquitoes: systematic review and meta-analysis.PLoS medicine · 2014Pooled it
- Design of a study to determine the impact of insecticide resistance on malaria vector control: a multi-country investigation.Malaria journal · 2015Trial
- Coordinated regulation of glutathione S-transferases confers metabolic flexibility in multi-insecticide-resistant Frankliniella occidentalis (Pergande).Journal of advanced research · 2026Article
- Insecticide resistance in mosquitoes: Current status, mechanism, monitoring and innovative strategies for sustainable vector control.Molecular biology reports · 2026Review
- Mechanisms of carbamate resistance in the malaria vector:Parasite epidemiology and control · 2026Review
- Insecticide resistance profiles of Anopheles arabiensis and relationship with Microsporidia MB infection in two rice agroecosystems in Kenya.Parasites & vectors · 2026Article
- Comparative analysis reveals concentration-dependent and site-specific detoxification gene expression patterns in pyrethroid-resistant Anopheles gambiae s.l. from Accra, Ghana.Scientific reports · 2026Article
- Two independent regulatory mechanisms synergistically contribute to P450-mediated insecticide resistance in a lepidopteran pest, Spodoptera exigua.BMC biology · 2025Article
- Omics Approaches in Understanding Insecticide Resistance in Mosquito Vectors.International journal of molecular sciences · 2025Review
- Inhibition of transcriptional regulation of detoxification genes contributes to insecticide resistance management in Spodoptera exigua.Communications biology · 2025Article
- Insecticide resistant Anopheles from Ethiopia but not Burkina Faso show a microbiota composition shift upon insecticide exposure.Parasites & vectors · 2025Article
- Mechanisms of transcriptional regulation inProceedings. Biological sciences · 2024Article
- Functional Validation of Endogenous Redox PartnerInternational journal of molecular sciences · 2024Article
- Exploring the molecular mechanisms of increased intensity of pyrethroid resistance in Central African population of a major malaria vectorEvolutionary applications · 2024Article
- Article
- Mechanisms of transcriptional regulation inbioRxiv : the preprint server for biology · 2023Article
- Chlorfenapyr metabolism by mosquito P450s associated with pyrethroid resistance identifies potential activation markers.Scientific reports · 2023Article
- Molecular drivers of insecticide resistance in the Sahelo-Sudanian populations of a major malaria vector Anopheles coluzzii.BMC biology · 2023Article
75 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 4 countries.
Funding
Abstract
In the last decade there have been marked reductions in malaria incidence in sub-Saharan Africa. Sustaining these reductions will rely upon insecticides to control the mosquito malaria vectors. We report that in the primary African malaria vector, Anopheles gambiae sensu stricto, a single enzyme, CYP6M2, confers resistance to two classes of insecticide. This is unique evidence in a disease vector of cross-resistance associated with a single metabolic gene that simultaneously reduces the efficacy of two of the four classes of insecticide routinely used for malaria control. The gene-expression profile of a highly DDT-resistant population of A. gambiae s.s. from Ghana was characterized using a unique whole-genome microarray. A number of genes were significantly overexpressed compared with two susceptible West African colonies, including genes from metabolic families previously linked to insecticide resistance. One of the most significantly overexpressed probe groups (false-discovery rate-adjusted P < 0.0001) belonged to the cytochrome P450 gene CYP6M2. This gene is associated with pyrethroid resistance in wild A. gambiae s.s. populations) and can metabolize both type I and type II pyrethroids in recombinant protein assays. Using in vitro assays we show that recombinant CYP6M2 is also capable of metabolizing the organochlorine insecticide DDT in the presence of solubilizing factor sodium cholate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.