ReviewImmunologic research2012
Revisiting the old link between infection and autoimmune disease with commensals and T helper 17 cells.
Review in Immunologic research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Healthy Patients Are Not the Best Controls for Microbiome-Based Clinical Studies: Example of Sjögren's Syndrome in a Systematic Review.Frontiers in immunology · 2021Pooled it
- Regulation of inflammation by microbiota interactions with the host.Nature immunology · 2017Review
- The MHC locus and genetic susceptibility to autoimmune and infectious diseases.Genome biology · 2017Review
- Close Encounters of the First Kind: Innate Sensors and Multiple Sclerosis.Molecular neurobiology · 2017Review
- Apoptosis in response to microbial infection induces autoreactive TH17 cells.Nature immunology · 2016Article
- The Autoimmune Ecology.Frontiers in immunology · 2016Review
- Unresolved issues in theories of autoimmune disease using myocarditis as a framework.Journal of theoretical biology · 2015Review
- Role of viruses and bacteria-virus interactions in autoimmunity.Current opinion in immunology · 2014Review
- Inflammation and vitamin D: the infection connection.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Review
- Death-defining immune responses after apoptosis.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2014Review
- Rheumatic diseases and the microbiome.International journal of rheumatic diseases · 2014Article
- Complexities in the relationship between infection and autoimmunity.Current allergy and asthma reports · 2014Review
- Coherent somatic mutation in autoimmune disease.PloS one · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Genetic composition and major histocompatibility complex polymorphisms unequivocally predispose to autoimmune disease, but environmental factors also play a critical role in precipitating disease in susceptible individuals. Notorious among these has been microbial infection. Older studies describing associations between microbial infection and autoimmune disease are now followed by new studies demonstrating correlations between susceptibility to autoimmune disease and commensal colonization of the intestinal tract. T helper 17 (T(H)17) cells have gained a prominent role in autoimmune disease, and notably, their development within the intestine has been linked to colonization with specific commensal bacteria. Here, we consider current views on how microbes, T(H)17 cells, and autoimmunity are connected. We speculate on how the intricate relationships among commensal, pathogen, and the host might ultimately determine susceptibility to autoimmune disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.