ArticleAmerican journal of hematology2012
Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2.
Article in American journal of hematology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Lack of Hfe and TfR2 in Macrophages Impairs Iron Metabolism in the Spleen and the Bone Marrow.International journal of molecular sciences · 2024Article
- Transferrin receptor 1: keeper of HFE.Blood · 2023Article
- Engineering Peptide Inhibitors of the HFE-Transferrin Receptor 1 Complex.Molecules (Basel, Switzerland) · 2022Article
- Coordination of iron homeostasis by bone morphogenetic proteins: Current understanding and unanswered questions.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Hepcidin Signaling in Health and Disease: Ironing Out the Details.Hepatology communications · 2021Review
- Extrahepatic deficiency of transferrin receptor 2 is associated with increased erythropoiesis independent of iron overload.The Journal of biological chemistry · 2020Article
- A Short Review of Iron Metabolism and Pathophysiology of Iron Disorders.Medicines (Basel, Switzerland) · 2019Review
- Liver iron sensing and body iron homeostasis.Blood · 2019Review
- Iron as a Therapeutic Target inPharmaceuticals (Basel, Switzerland) · 2018Review
- Haemochromatosis.Nature reviews. Disease primers · 2018Review
- The hemochromatosis protein HFE signals predominantly via the BMP type I receptor ALK3 in vivo.Communications biology · 2018Article
- Iron homeostasis: An anthropocentric perspective.The Journal of biological chemistry · 2017Review
- A Red Carpet for Iron Metabolism.Cell · 2017Review
- Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation.The Journal of biological chemistry · 2015Review
- Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin.Journal of molecular medicine (Berlin, Germany) · 2015Article
- Hepcidin: regulation of the master iron regulator.Bioscience reports · 2015Review
- Article
- Relationship of Baseline Hemoglobin Level with Serum Ferritin, Postphlebotomy Hemoglobin Changes, and Phlebotomy Requirements among HFE C282Y Homozygotes.BioMed research international · 2015Article
- Article
- Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches.Hematology/oncology clinics of North America · 2014Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Hereditary hemochomatosis (HH) is caused by mutations in several genes, including HFE and transferrin receptor-2 (TFR2). Loss of either protein decreases expression of the iron regulatory hormone hepcidin by the liver, leading to inappropriately high iron uptake from the diet, and resulting in systemic iron overload. In tissue culture, overexpressed HFE and TFR2 physically interact. Hepatocellular overexpression of Hfe in vivo increases hepcidin expression, despite an associated decrease in Tfr2. On this basis, we hypothesized that Tfr2 would not be required for Hfe-dependent up-regulation of hepcidin. We show that hepatocellular overexpression of Hfe in Tfr2(Y245X/Y245X) mice leads to hepcidin induction eventuating in iron deficiency and a hypochromic, microcytic anemia. Furthermore, coimmunoprecipitation studies using liver lysates did not provide evidence for physical interaction between Hfe and Tfr2 in vivo. In conclusion, we demonstrate that Tfr2 is not essential for Hfe-mediated induction of hepcidin expression, supporting the possibility that TFR2 may regulate iron metabolism in an HFE-independent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.