ArticleVirulence
Acidic pH: enemy or ally for enteric bacteria?
Article in Virulence. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Genotypic and Phenotypic Characterization of Salmonella Typhimurium Strains Isolated from Swine in the Southern Region of Brazil.Current microbiology · 2026Article
- Investigating Stress Tolerance of MultipleInternational journal of microbiology · 2026Article
- Isolation and Characterization of Lactic Acid Bacteria From "International journal of microbiology · 2025Article
- Response mechanisms to acid stress promote LF82 replication in macrophages.Frontiers in cellular and infection microbiology · 2023Article
- Zebrafish: an efficient vertebrate model for understanding role of gut microbiota.Molecular medicine (Cambridge, Mass.) · 2022Review
- The Transcription of Flagella of EnteropathogenicMicroorganisms · 2022Article
- Rhizospheric microbial consortium ofFrontiers in microbiology · 2022Article
- Low base-substitution mutation rate and predominance of insertion-deletion events in the acidophilic bacteriumEcology and evolution · 2021Article
- Comparative genomics ofMicrobial genomics · 2021Article
- The zebrafish as a model for gastrointestinal tract-microbe interactions.Cellular microbiology · 2020Review
- Acetylation Regulates Survival of Salmonella enterica Serovar Typhimurium under Acid Stress.Applied and environmental microbiology · 2015Article
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The first stress that foodborne pathogens find upon ingestion is the very acidic pH of the stomach of the host. In addition, intracellular pathogens like Salmonella are submitted to low pH inside the host cells. Two general acid survival systems are found in these organisms: acid resistance mechanisms and acid tolerance responses. These mechanisms involve the synthesis of a series of acid shock proteins. Only a subset of these proteins is directly involved in acid survival. This is related to the fact that low pH is not only a stress to cope with, but it is also an important signal that indicates to the bacterium that it is in a potential host environment and that triggers the induction of many virulence genes. Asr is an acid shock protein that supports growth of Escherichia coli at moderate acidity. In this issue of Virulence, Allam et al. investigate the role of STM1485, the homologous of asr in Salmonella enterica serovar Typhimurium, in acid survival and virulence. Although STM1485 is not required for acid survival of S. enterica, it is necessary for intracellular replication in human epithelial cells and murine macrophages, and to prevent the progression of the Salmonella-containing vacuole along the degradative pathway. In addition, Allam et al. are able to show that the defects of the STM1485 mutant at the cellular level correlate with reduced virulence in the mouse model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.