ArticleJournal of perinatology : official journal of the California Perinatal Association2012
Prolonged persistent patent ductus arteriosus: potential perdurable anomalies in premature infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Safety and Effectiveness of the KA Micro Plug for Treatment of Patent Ductus Arteriosus in Preterm Low-Birth-Weight Infants: Retrospective Analysis From a Multicenter Registry.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Clinical Impact of the PDA and Its Management on Outcomes of Preterm Infants with NEC: A Review.American journal of perinatology · 2026Review
- Trends in bronchopulmonary dysplasia and 15-year evolution in respiratory and hemodynamic management of very premature infants.Scientific reports · 2025Observational
- Combination pharmacotherapy for patent ductus arteriosus: Rationale and evidence.Seminars in perinatology · 2023Review
- Continuing interventions in a quality improvement bundle to reduce bronchopulmonary dysplasia.World journal of pediatrics : WJP · 2022Article
- Article
- The patent ductus arteriosus management debate: it's not over yet.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Bedside cardiopulmonary ultrasonography evaluates lung water content in very low-weight preterm neonates with patent ductus arteriosus.World journal of clinical cases · 2021Article
- Oral Versus Intravenous Medications for Treatment of Patent Ductus Arteriosus in Preterm Neonates: A Cost-Saving Initiative.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021Article
- Patent Ductus Arteriosus of the Preterm Infant.Pediatrics · 2020Review
- Early NT-proBNP levels as a screening tool for the detection of hemodynamically significant patent ductus arteriosus during the first week of life in very low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2018Observational
- Reduced oxygen concentration for the resuscitation of infants with congenital diaphragmatic hernia.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Relevance of clinical features in the prognosis of bronchopulmonary dysplasia in premature infants.Experimental and therapeutic medicine · 2017Article
- Transcatheter closure of PDA in premature babies less than 2 kg.Anatolian journal of cardiology · 2017Article
- Management of patent ductus arteriosus in premature infants.Indian journal of pediatrics · 2015Review
- Physiological marker and surgical ligation of patent ductus arteriosus in neonates.African journal of paediatric surgery : AJPSArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePatent ductus arteriosus (PDA) is a common condition among preterm infants. Controversy exists regarding the risk-benefit ratio of early closure of PDAs by either medical or surgical treatments. On the other hand, potential morbidities associated with no or delayed closure has not been well studied. The objective of the study was to determine if there is an association of prolonged persistent PDA (PP-PDA) with various morbidities in infants ≤28 weeks or 1250 g. STUDY
designThis matched case-control analysis includes preterm infants with a diagnosis of PDA over a period of 28 months in a single level III center in the USA. The predictive variable was the presence of a PP-PDA (PDA>3 weeks). Cases were infants with PP-PDA and controls were those with PDA but not PP-PDA (two controls for each case). Outcome variables included days on mechanical ventilation and with oxygen treatment, length of hospital stay, bronchopulmonary dysplasia (BPD), retinopathy of prematurity stage III-V (ROP) necrotizing enterocolitis grade II or more (NEC), delayed growth, direct hyperbilirubinemia >4 mg dl(-1) and osteopenia of prematurity. Data was obtained from database collected prospectively and from the review of clinical records when necessary. Statistics included ANOVA, Kaplan-Meier curves and χ (2). Significance was set at P<0.05.
resultPP-PDA was associated with a significant increase in the number of days of mechanical ventilation, oxygen treatment and length of hospital stay, and in the rates of BPD (60% vs 4.5%), NEC (29% vs 5%), ROP (43% vs 5%), direct hyperbilirubinemia (41% vs 3%), osteopenia (44% vs 6%), parenteral nutrition for >40 days (70% vs 21%), tracheostomy during the hospitalization (15% vs 0%) and delayed growth (70% vs 21%), were also significantly higher in babies with PP-PDA.
conclusionA prolonged exposure to PDA does not seem to be inconsequential for some infants and is associated with an increase prevalence of severe morbidities with potential long lasting effects.
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Registered trials
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