ArticleImmunogenetics2012
Low MHC class II diversity in the Tasmanian devil (Sarcophilus harrisii).
Article in Immunogenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Improved high-throughput MHC typing for non-model species using long-read sequencing.Molecular ecology resources · 2022Pooled it
- Plethora of New Marsupial Genomes Informs Our Knowledge of Marsupial MHC Class II.Genome biology and evolution · 2024Article
- The complex effects of modern oncogenic environments on the fitness, evolution and conservation of wildlife species.Evolutionary applications · 2024Article
- Best genome sequencing strategies for annotation of complex immune gene families in wildlife.GigaScience · 2022Article
- Restoring faith in conservation action: Maintaining wild genetic diversity through the Tasmanian devil insurance program.iScience · 2022Article
- Genetic diversity and disease: The past, present, and future of an old idea.Evolution; international journal of organic evolution · 2022Article
- Annotation of immune genes in the extinct thylacine (Thylacinus cynocephalus).Immunogenetics · 2021Article
- Fecal Viral Diversity of Captive and Wild Tasmanian Devils Characterized Using Virion-Enriched Metagenomics and Metatranscriptomics.Journal of virology · 2019Article
- Complex problems need detailed solutions: Harnessing multiple data types to inform genetic management in the wild.Evolutionary applications · 2019Article
- Conserving adaptive potential: lessons from Tasmanian devils and their transmissible cancer.Conservation genetics (Print) · 2019Article
- Lessons learnt from the Tasmanian devil facial tumour regarding immune function in cancer.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Transcriptome sequencing of the long-nosed bandicoot (Perameles nasuta) reveals conservation and innovation of immune genes in the marsupial order Peramelemorphia.Immunogenetics · 2018Article
- Low genetic variation in the MHC class II DRB gene and MHC-linked microsatellites in endangered island populations of the leopard cat (Prionailurus bengalensis) in Japan.Immunogenetics · 2018Article
- The role of MHC genes in contagious cancer: the story of Tasmanian devils.Immunogenetics · 2017Review
- A Sixth Modality of Infectious Disease: Contagious Cancer from Devils to Clams and Beyond.PLoS pathogens · 2016Review
- The identification of immune genes in the milk transcriptome of the Tasmanian devil (Sarcophilus harrisii).PeerJ · 2016Article
- Identification and analysis of divergent immune gene families within the Tasmanian devil genome.BMC genomics · 2015Article
- Positive selection drives the evolution of a major histocompatibility complex gene in an endangered Mexican salamander species complex.Immunogenetics · 2015Article
- Diversity in the Toll-like receptor genes of the Tasmanian devil (Sarcophilus harrisii).Immunogenetics · 2015Article
- Characterisation of non-classical MHC class I genes in the Tasmanian devil (Sarcophilus harrisii).Immunogenetics · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The largest remaining carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii), is currently under threat of extinction due to a fatal contagious cancer-devil facial tumour disease. Low major histocompatibility complex (MHC) class I diversity is believed to have contributed to the transmission of the tumour allograft through devil populations. Here, we report low MHC class II variability in this species, with DA β chain genes (Saha-DAB1, 2 and 3) exhibiting very limited diversity and the sole α chain gene (Saha-DAA) monomorphic. Three, six and three alleles were found at Saha-DAB1, 2 and 3, respectively, with a predominant allele found at each locus. Heterozygosity at these three loci is low in the eastern population and modestly higher in northwestern individuals. The results are indicative of a selective sweep likely due to an infectious disease resulting in the fixation of selectively favoured alleles and depletion of genetic diversity at devil class II loci. Several attempts were made to isolate the other marsupial classical class II gene family, namely, DB, resulting in only one DBB pseudogene being found. These findings further support the view that this species has a compromised capacity to respond to pathogen evolution, emerging infectious diseases and environmental changes.
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