ArticleAJNR. American journal of neuroradiology2012
Iron deposition on SWI-filtered phase in the subcortical deep gray matter of patients with clinically isolated syndrome may precede structure-specific atrophy.
Article in AJNR. American journal of neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Iron accumulation in multiple sclerosis and implications for cognitive and clinical progression: a systematic review of advanced neuroimaging studies.Journal of neurology · 2026Pooled it
- Reduced Gray-White Matter Contrast in Chronic Posttraumatic Stress Disorder in World Trade Center Responders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Cerebral iron deposition in the Globus pallidus and Substantia nigra of aging dogs and cats presenting as bilateral hypointensity on T2w and iron-sensitive MRI sequences (SWI, T2*).Frontiers in veterinary science · 2026Article
- Dialysis adequacy and hemoglobin levels predict cerebral atrophy in maintenance-hemodialysis patients.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Smoldering lesions in MS: if you like it then you should put a rim on it.Neuroradiology · 2022Article
- Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fMRI study.International journal of ophthalmology · 2021Article
- Iron Rims as an Imaging Biomarker in MS: A Systematic Mapping Review.Diagnostics (Basel, Switzerland) · 2020Review
- Current Methods of Magnetic Resonance for Noninvasive Assessment of Molecular Aspects of Pathoetiology in Multiple Sclerosis.International journal of molecular sciences · 2020Review
- Thalamic Injury and Cognition in Multiple Sclerosis.Frontiers in neurology · 2020Review
- Review
- Primary biliary cholangitis patients exhibit MRI changes in structure and function of interoceptive brain regions.PloS one · 2019Article
- A Radiodensity Histogram Study of the Brain in Multiple Sclerosis.Tomography (Ann Arbor, Mich.) · 2018Article
- Quantitative Susceptibility Mapping of the Thalamus: Relationships with Thalamic Volume, Total Gray Matter Volume, and T2 Lesion Burden.AJNR. American journal of neuroradiology · 2018Article
- Article
- Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain.NeuroImage. Clinical · 2018Article
- Iron-related gene variants and brain iron in multiple sclerosis and healthy individuals.NeuroImage. Clinical · 2018Article
- Susceptibility Weighted MRI in Rodents at 9.4 T.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Heterogeneity of Cortical Lesion Susceptibility Mapping in Multiple Sclerosis.AJNR. American journal of neuroradiology · 2017Article
- Inversion recovery ultrashort echo time magnetic resonance imaging: A method for simultaneous direct detection of myelin and high signal demonstration of iron deposition in the brain - A feasibility study.Magnetic resonance imaging · 2017Article
- An illustrated comparison of processing methods for MR phase imaging and QSM: combining array coil signals and phase unwrapping.NMR in biomedicine · 2017Review
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Authors and funding
10 authors.
Funding
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Abstract
background and purposeIncreasing evidence suggests that iron deposition is present in the later stages of MS. In this study we examined abnormal phase values, indicative of increased iron content on SWI-filtered phase images of the SDGM in CIS patients and HC. We also examined the association of abnormal phase with conventional MR imaging outcomes at first clinical onset. MATERIALS AND
methodsForty-two patients with CIS (31 female, 11 male) and 65 age and sex-matched HC (41 female, 24 male) were scanned on a 3T scanner. Mean age was 40.1 (SD = 10.4) years in patients with CIS, and 42.8 (SD = 14) years in HC, while mean disease duration was 1.2 years (SD = 1.3) in patients with CIS. MP-APT, NPTV, and normalized volume measurements were derived for all SDGM structures. Parametric and nonparametric group-wise comparisons were performed, and associations were determined with other MR imaging metrics.
resultsPatients with CIS had significantly increased MP-APT (P = .029) and MP-APT volume (P = .045) in the pulvinar nucleus of the thalamus compared with HC. Furthermore, the putamen (P = .004), caudate (P = .035), and total SDGM (P = .048) displayed significant increases in MP-APT volume, while MP-APT was also significantly increased in the putamen (P = .029). No global or regional volumetric MR imaging differences were found between the study groups. Significant correlations were observed between increased MP-APT volumes of total SDGM, caudate, thalamus, hippocampus, and substantia nigra with white matter atrophy and increased T2 lesion volume (P < .05).
conclusionPatients with CIS showed significantly increased content and volume of iron, as determined by abnormal SWI-phase measurement, in the various SDGM structures, suggesting that iron deposition may precede structure-specific atrophy.
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