ArticleJournal of Alzheimer's disease : JAD2012
Structural brain alterations before mild cognitive impairment in ADNI: validation of volume loss in a predefined antero-temporal region.
Article in Journal of Alzheimer's disease : JAD, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Risk factors underlying brain structure change rate in cognitive decline: Results from genomewide and phenomewide investigations.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Regional age-related atrophy after screening for preclinical alzheimer disease.Neurobiology of aging · 2022Article
- Contribution of mixed pathology to medial temporal lobe atrophy in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Spontaneous oscillatory markers of cognitive status in two forms of dementia.Human brain mapping · 2019Article
- The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases.Journal of neuropathology and experimental neurology · 2018Review
- Brain imaging of neurovascular dysfunction in Alzheimer's disease.Acta neuropathologica · 2016Review
- APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Article
- Parahippocampal white matter volume predicts Alzheimer's disease risk in cognitively normal old adults.Neurobiology of aging · 2014Article
- A focus on structural brain imaging in the Alzheimer's disease neuroimaging initiative.Biological psychiatry · 2014Review
- MTA index: a simple 2D-method for assessing atrophy of the medial temporal lobe using clinically available neuroimaging.Frontiers in aging neuroscience · 2014Article
- A neurodegenerative vascular burden index and the impact on cognition.Frontiers in aging neuroscience · 2014Article
- Understanding cognitive deficits in Alzheimer's disease based on neuroimaging findings.Trends in cognitive sciences · 2013Review
- Using a cognitive orthosis to support older adults during meal preparation: Clinicians' perspective on COOK technology.Journal of rehabilitation and assistive technologies engineeringArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Volume losses in the medial temporal lobe, posterior cingulated, and orbitofrontal region have been observed in Alzheimer's disease (AD). Smaller reductions in similar regions have also been reported in amnestic mild cognitive impairment (aMCI), a canonical precursor to AD. We previously demonstrated that volume loss in bilateral anteromedial temporal lobe is present at baseline in longitudinally followed normal subjects who later developed MCI or AD. In this study we compared grey matter volumes within this predefined anteromedial temporal region (AMTR) at baseline between: 1) normal subjects enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) who subsequently developed cognitive complaints as reflected in a CDR memory box score of 0.5; and 2) normal subjects who remained normal over a median of 48 months of follow-up (CDR sum of boxes 0). We found significantly decreased volume within AMTR in the ADNI memory complainers. To relate AMTR results to those from conventional anatomy, we demonstrate that volumes extracted with the ICBM amygdala region had the best correspondence with AMTR volumes. In contrast, regions that have demonstrated volume loss in frank MCI and AD in ADNI, e.g., the posterior cingulate, did not show volume loss. These findings provide independent confirmation that volume changes preceding MCI occur in AMTR, a region of overlap between amygdala and anterior hippocampus.
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Registered trials
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