ReviewAnnals of biomedical engineering2012
Multiscale systems biology and physics of thrombosis under flow.
Review in Annals of biomedical engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 68 citations in OpenAlex.
- Article
- The association between admission mean corpuscular volume and preoperative deep venous thrombosis in geriatrics hip fracture: a retrospective study.BMC musculoskeletal disorders · 2024Article
- Effects of the interactions between platelets with other cells in tumor growth and progression.Frontiers in immunology · 2023Review
- COVID-19 and thrombosis: The role of hemodynamics.Thrombosis research · 2022Review
- Computationally Driven Discovery in Coagulation.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- Red blood cells: the forgotten player in hemostasis and thrombosis.Journal of thrombosis and haemostasis : JTH · 2019Review
- Multiscale systems biology of trauma-induced coagulopathy.Wiley interdisciplinary reviews. Systems biology and medicine · 2018Review
- Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics.Clinical pharmacology and therapeutics · 2018Article
- Model predictions of deformation, embolization and permeability of partially obstructive blood clots under variable shear flow.Journal of the Royal Society, Interface · 2017Article
- Fibrin mechanical properties and their structural origins.Matrix biology : journal of the International Society for Matrix Biology · 2017Review
- Computational study for the effects of coil configuration on blood flow characteristics in coil-embolized cerebral aneurysm.Medical & biological engineering & computing · 2017Article
- Dynamics of blood flow and thrombus formation in a multi-bypass microfluidic ladder network.Cellular and molecular bioengineering · 2017Article
- Role of red blood cells in haemostasis and thrombosis.ISBT science series · 2017Article
- Fibrin Formation, Structure and Properties.Sub-cellular biochemistry · 2017Review
- Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach.PLoS computational biology · 2015Article
- A comprehensive study on different modelling approaches to predict platelet deposition rates in a perfusion chamber.Scientific reports · 2015Article
- Multi-scale biological and physical modelling of the tumour micro-environment.Drug discovery today. Disease models · 2015Article
- Fluid Mechanics of Blood Clot Formation.Annual review of fluid mechanics · 2015Article
- Platelet dynamics in three-dimensional simulation of whole blood.Biophysical journal · 2014Article
- Systems biology of platelet-vessel wall interactions.Advances in experimental medicine and biology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Blood clotting under hemodynamic conditions involves numerous multiscale interactions from the molecular scale to macroscopic vessel and systemic circulation scales. Transmission of shear forces to platelet receptors such as GPIbα, P-selectin, α(2)β(1), and α(2b)β(3) controls adhesion dynamics. These forces also drive membrane tether formation, cellular deformation, and mechanosignaling in blood cells. Blood flow results in red blood cell (RBC) drift towards the center of the vessel along with a near-wall plasma layer enriched with platelets. RBC motions also dramatically enhance platelet dispersion. Trajectories of individual platelets near a thrombotic deposit dictate capture-activation-arrest dynamics as these newly arriving platelets are exposed to chemical gradients of ADP, thromboxane, and thrombin within a micron-scale boundary layer formed around the deposit. If shear forces are sufficiently elevated (>50 dyne/cm(2)), the largest polymers of von Willebrand Factor may elongate with concomitant shear-induced platelet activation. Finally, thrombin generation enhances platelet recruitment and clot strength via fibrin polymerization. By combination of coarse-graining, continuum, and stochastic algorithms, the numerical simulation of the growth rate, composition, and occlusive/embolic potential of a thrombus now spans multiscale phenomena. These simulations accommodate particular flow geometries, blood phenotype, pharmacological regimen, and reactive surfaces to help predict disease risk or response to therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.