ArticleThe Journal of allergy and clinical immunology2012
Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life.
Article in The Journal of allergy and clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00114881 (Urban Environment and Childhood Asthma), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Urban Environment and Childhood Asthma (URECA)
Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Population-specific heterogeneity in ontogeny of the broadly-conserved blood transcriptional program during the first week of life.Nature communications · 2026Article
- The role of gut microbiome in the complex relationship between respiratory tract infection and asthma.Frontiers in microbiology · 2023Review
- Effects of life-stage and passive tobacco smoke exposure on pulmonary innate immunity and influenza infection in mice.Journal of toxicology and environmental health. Part A · 2022Article
- Vertically transferred maternal immune cells promote neonatal immunity against early life infections.Nature communications · 2021Article
- Evolving concepts in how viruses impact asthma: A Work Group Report of the Microbes in Allergy Committee of the American Academy of Allergy, Asthma & Immunology.The Journal of allergy and clinical immunology · 2020Article
- Diminished secretion and function of IL-29 is associated with impaired IFN-α response of neonatal plasmacytoid dendritic cells.Journal of leukocyte biology · 2019Article
- MicroRNA 27b-3p Modulates SYK in Pediatric Asthma Induced by Dust Mites.Frontiers in pediatrics · 2018Article
- Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy.The Journal of allergy and clinical immunology · 2017Observational
- [The interactions between microorganisms and the small airways. A paediatric focus].Revue des maladies respiratoires · 2017Review
- Lessons learned from birth cohort studies conducted in diverse environments.The Journal of allergy and clinical immunology · 2017Review
- Impaired virus replication and decreased innate immune responses to viral infections in nasal epithelial cells from patients with allergic rhinitis.Clinical and experimental immunology · 2017Article
- The influence of atopy and asthma on immune responses in inner-city adults.Immunity, inflammation and disease · 2016Article
- Review
- Maternal pregnancy weight gain and cord blood iron status are associated with eosinophilia in infancy.Journal of perinatology : official journal of the California Perinatal Association · 2015Observational
- Host-microbe interactions in distal airways: relevance to chronic airway diseases.European respiratory review : an official journal of the European Respiratory Society · 2015Review
- Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma.The Journal of allergy and clinical immunology · 2014Article
- Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma.Epigenetics · 2014Article
- Ontogeny of early life immunity.Trends in immunology · 2014Review
- Interferon gene expression in sputum cells correlates with the Asthma Index Score during virus-induced exacerbations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
- Immunity to RSV in Early-Life.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundViral respiratory tract infections are the leading cause of acute illness during infancy and are closely linked to chronic inflammatory airway diseases later in life. However, the determinants of susceptibility to acute respiratory tract infections still need to be defined.
objectiveWe investigated whether the individual variation in antiviral response at birth determines the risk for acute respiratory tract illness in the first year of life.
methodsWe studied 82 children who were enrolled in a birth cohort study of inner-city children with at least 1 parent with allergy or asthma. We cultured cord blood monocytes and assessed IFNG and CCL5 mRNA production at 24 hours after inoculation with respiratory syncytial virus. We also monitored the frequency of acute respiratory tract illness at 3-month intervals and analyzed nasal lavage samples for respiratory tract viruses at the time of illness during the first year.
resultsRespiratory tract infection was reported for 88% of subjects, and respiratory tract viruses were recovered in 74% of symptomatic children. We observed a wide range of antiviral responses in cord blood monocytes across the population. Furthermore, a decrease in production of IFNG (but not CCL5) mRNA in response to respiratory syncytial virus infection of monocytes was associated with a significant increase in the frequency of upper respiratory tract infections (r = -0.42, P < .001) and the prevalence of ear and sinus infections, pneumonias, and respiratory-related hospitalizations.
conclusionIndividual variations in the innate immune response to respiratory tract viruses are detectable even at birth, and these differences predict the susceptibility to acute respiratory tract illness during the first year of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.