Evidence map›Paper›PMID 22459748›Full record

Trial reportJournal of vascular surgery2012

Optimal exercise program length for patients with claudication.

Andrew W Gardner, Polly S Montgomery, Donald E Parker

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of vascular surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Exercise for intermittent claudication.The Cochrane database of systematic reviews · 2017
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Enrollment of Historically Underrepresented Groups in Peripheral Arterial Disease Trials: A Systematic Review.Journal of the Society for Cardiovascular Angiography & Interventions · 2026
    Review
  12. Article
  13. Article
  14. Exercise Therapy in the Management of Peripheral Arterial Disease.Mayo Clinic proceedings. Innovations, quality & outcomes · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Adherence and exercise mode in supervised exercise therapy for peripheral artery disease.Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrew W GardnerGeneral Clinical Research Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA. andrew-gardner@ouhsc.edu
Polly S Montgomery
Donald E Parker

Funding

UPPER EXTREMITY TRAINING FOR CHRONIC STROKEP60AG012583 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI GOLDBERG, ANDREW P · 1994 to 2005
$7.8M
Home-based vs. Supervised Exercise for ClaudicantsR01AG024296 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI GARDNER, ANDREW W · 2006 to 2010
$1.4M
ISOLATION OF PROTEIN COMPLEX INVOLVED IN BLOOM SYNDROMEZ01AG000657 · NIA · NATIONAL INSTITUTE ON AGING · PI WANG, WEIDONG · 2000 to 2008
$636k
EXERCISE REHABILITATION OF YOUNGER AND OLDER CLAUDICANTSK01AG000657 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI GARDNER, ANDREW W · 1994 to 1998
–
Intramural NIH HHS Z01 AG000657NIA NIH HHS K01 AG000657NIA NIH HHS P60 AG012583NIA NIH HHS P60-AG12583NIA NIH HHS R01 AG024296NIA NIH HHS R01-AG-24296PHS HHS K01-00657
6 · The paper itself

Abstract

backgroundThis prospective, randomized controlled clinical trial determined whether an optimal exercise program length exists to efficaciously change claudication onset time (COT) and peak walking time (PWT) in patients with peripheral artery disease and claudication.

methodsThe study randomized 142 patients to supervised exercise (n = 106) or a usual care control group (n = 36), with 80 completing the exercise program and 27 completing the control intervention. The exercise program consisted of intermittent walking to nearly maximal claudication pain 3 days per week. COT and PWT were the primary outcomes obtained from a treadmill exercise test at baseline and bimonthly during the study.

resultsAfter exercise, changes in COT (P < .001) and PWT (P < .001) were consistently greater than changes after the control intervention. In the exercise program, COT and PWT increased from baseline to month 2 (P < .05) and from months 2 to 4 (P < .05) but did not significantly change from months 4 to 6 (P > .05). When changes were expressed per mile walked during the first 2 months, middle 2 months, and final 2 months of exercise, COT and PWT only increased during the first 2 months (P < .05).

conclusionsExercise-mediated gains in COT and PWT occur rapidly within the first 2 months of exercise rehabilitation and are maintained with further training. The clinical significance is that a relatively short 2-month exercise program may be preferred to a longer program to treat claudication because adherence is higher, costs associated with personnel and use of facilities are lower per patient, and more patients can be trained for a given amount of personnel time and resource utilization.

Indexed as

Exercise TherapyAgedBaltimoreChi-Square DistributionExercise TestExercise ToleranceFemaleHumansIntermittent ClaudicationMaleMiddle AgedPatient CompliancePeripheral Arterial DiseaseProspective StudiesRecovery of FunctionRegional Blood Flow

Identifiers

PMID22459748
PMCPMC3340530

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.