ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2012
FOXO3 gene variants and human aging: coding variants may not be key players.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Association Analysis of FOXO3 Longevity Variants With Blood Pressure and Essential Hypertension.American journal of hypertension · 2016Pooled it
- FOXO3 variants are beneficial for longevity in Southern Chinese living in the Red River Basin: A case-control study and meta-analysis.Scientific reports · 2015Pooled it
- GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Pooled it
- Association between FOXO3A gene polymorphisms and human longevity: a meta-analysis.Asian journal of andrologyPooled it
- Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study.Aging cell · 2023Trial
- FOXO family and neurodegenerative diseases: Mechanisms of action and therapeutic potential.Redox biology · 2026Review
- FOXO family isoforms.Cell death & disease · 2023Review
- Article
- Novel Functional, Health, and Genetic Determinants of Cognitive Terminal Decline: Kuakini Honolulu Heart Program/Honolulu-Asia Aging Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Zoledronate Extends Health Span and Survival via the Mevalonate Pathway in a FOXO-dependent Manner.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Mechanistic insights into the role of FOXO in diabetic retinopathy.American journal of translational research · 2022Review
- Article
- The emerging role of circular RNAs in cardiovascular diseases.Journal of physiology and biochemistry · 2021Review
- No Association Between a Genetic Variant ofIndian journal of clinical biochemistry : IJCB · 2021Article
- Therapeutic strategies targeting FOXO transcription factors.Nature reviews. Drug discovery · 2021Review
- Observational
- Review
- Longevity-Associated Forkhead Box O3 (FOXO3) Single Nucleotide Polymorphisms are Associated with Type 2 Diabetes Mellitus in Chinese Elderly Women.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells.PLoS genetics · 2019Article
- Analysis of FOXO3 Gene Polymorphisms Associated with Human Longevity.Methods in molecular biology (Clifton, N.J.) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
FOXO3 is generally recognized as a "master" gene in aging since its association with longevity has been replicated in multiple organisms and human populations. A group of single nucleotide polymorphisms in linkage disequilibrium with a coding region has been associated with human longevity, but the actual functional variant is unidentified. Therefore, we sequenced the coding region in our long-lived Japanese American population in order to enhance resources for fine mapping this region. We demonstrate that of 38 published variants, 6 are misalignments with homologous nonallelic sequences from FOXO3B (ZNF286B), a pseudogene on a different chromosome; 2 are attributable to ZNF286B only, and the remaining 30 were unconfirmed, indicating that they are very rare and not likely involved in longevity. Furthermore, we identified a novel, unique, nonsynonymous coding variant in exon 3 (Gly566Ala; rs138174682) that is prevalent in multiple ethnic groups but appeared too rare for major longevity effects in our study populations.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.