ReviewThe journals of gerontology. Series A, Biological sciences and medical sciences2012
Genes against aging.
Review in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Does Modulation of an Epigenetic Clock Define a Geroprotector?Advances in geriatric medicine and research · 2022Article
- A 25-y longitudinal dolphin cohort supports that long-lived individuals in same environment exhibit variation in aging rates.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Period and cohort-specific trends in life expectancy at different ages: Analysis of survival in high-income countries.SSM - population health · 2019Article
- Evaluation of Oxidative Stress in Cardiomyocytes during the Aging Process in Rats Treated with Resveratrol.Oxidative medicine and cellular longevity · 2018Article
- Article
- Articulating the Case for the Longevity Dividend.Cold Spring Harbor perspectives in medicine · 2016Review
- Mini-review: Retarding aging in murine genetic models of neurodegeneration.Neurobiology of disease · 2016Review
- Past, Present, and Future of Healthy Life Expectancy.Cold Spring Harbor perspectives in medicine · 2015Review
- "IDEAL" aging is associated with lower resting metabolic rate: the Baltimore Longitudinal Study of Aging.Journal of the American Geriatrics Society · 2014Article
- Death by transposition - the enemy within?BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- The hallmarks of aging.Cell · 2013Review
- Article
- Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- The genetics of age-related health outcomes.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Individual mutations in mice can slow aging: They extend life span by retarding a wide range of harmful, age-dependent changes in multiple cells and tissues. Evolutionary changes-by definition, changes in DNA sequence-can lead to even more dramatic postponement of age-dependent deterioration. Genetic variation within a species, for example among breeds of dogs, can also lead to major changes in aging rate, although there is not yet any strong evidence for similar genetic variation that modulates aging in rodents or humans. This essay compares different strategies for using genetic information to clarify questions in biogerontology, suggesting an emphasis on genes that can retard multiple forms of age-dependent dysfunction in parallel.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.