ArticleAddiction biology2014
Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations.
Article in Addiction biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 65 citations in OpenAlex.
- Synaptogyrin-3 plays a critical role in addiction-related dopamine dysfunction and behavioral maladaptations.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The use ofFrontiers in cell and developmental biology · 2026Review
- Cocaine Self-Administration Differentially Modulates the Content of Cholesterol, Progesterone, and Testosterone in the Brain and Plasma of Male Rats.Neuroendocrinology · 2025Article
- Monoamine Transporters in Drugs of Abuse: Insights from Fast Scan Cyclic Voltammetry.Advances in neurobiology · 2025Review
- Repeated Cocaine Intake Differentially Impacts Striatal DInternational journal of molecular sciences · 2023Article
- The transcriptional response to acute cocaine is inverted in male mice with a history of cocaine self-administration and withdrawal throughout the mesocorticolimbic system.Molecular and cellular neurosciences · 2023Article
- β2 nAChR Activation on VTA DA Neurons Is Sufficient for Nicotine Reinforcement in Rats.eNeuro · 2023Article
- Article
- Cocaine-regulated trafficking of dopamine transporters in cultured neurons revealed by a pH sensitive reporter.iScience · 2023Article
- Altered Accumbal Dopamine Terminal Dynamics Following Chronic Heroin Self-Administration.International journal of molecular sciences · 2022Article
- Effects of Methylphenidate on the Dopamine Transporter and Beyond.Current topics in behavioral neurosciences · 2022Article
- Enhanced heroin self-administration and distinct dopamine adaptations in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- An optimized procedure for robust volitional cocaine intake in mice.Experimental and clinical psychopharmacology · 2021Article
- Direct dopamine terminal regulation by local striatal microcircuitry.Journal of neurochemistry · 2020Review
- Cell-type and projection-specific dopaminergic encoding of aversive stimuli in addiction.Brain research · 2019Review
- Selective activation of Dopamine D3 receptors and norepinephrine transporter blockade enhances sustained attention.Neuropharmacology · 2019Article
- Granulocyte Colony Stimulating Factor Enhances Reward Learning through Potentiation of Mesolimbic Dopamine System Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Heterogeneous dopamine signals support distinct features of motivated actions: implications for learning and addiction.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Susceptibility to traumatic stress sensitizes the dopaminergic response to cocaine and increases motivation for cocaine.Neuropharmacology · 2017Article
- Prior Cocaine Experience Impairs Normal Phasic Dopamine Signals of Reward Value in Accumbens Shell.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Methylphenidate (MPH) is a commonly abused psychostimulant prescribed for the treatment of attention deficit hyperactivity disorder. MPH has a mechanism of action similar to cocaine (COC) and is commonly characterized as a dopamine transporter (DAT) blocker. While there has been extensive work aimed at understanding dopamine (DA) nerve terminal changes following COC self-administration, very little is known about the effects of MPH self-administration on the DA system. We used fast scan cyclic voltammetry in nucleus accumbens core slices from animals with a 5-day self-administration history of 40 injections/day of either MPH (0.56 mg/kg) or COC (1.5 mg/kg) to explore alterations in baseline DA release and uptake kinetics as well as alterations in the interaction of each compound with the DAT. Although MPH and COC have similar behavioral effects, the consequences of self-administration on DA system parameters were found to be divergent. We show that COC self-administration reduced DAT levels and maximal rates of DA uptake, as well as reducing electrically stimulated release, suggesting decreased DA terminal function. In contrast, MPH self-administration increased DAT levels, DA uptake rates and DA release, suggesting enhanced terminal function, which was supported by findings of increased metabolite/DA tissue content ratios. Tyrosine hydroxylase messenger RNA, protein and phosphorylation levels were also assessed in both groups. Additionally, COC self-administration reduced COC-induced DAT inhibition, while MPH self-administration increased MPH-induced DAT inhibition, suggesting opposite pharmacodynamic effects of these two drugs. These findings suggest that the factors governing DA system adaptations are more complicated than simple DA uptake blockade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.