ArticleJournal of clinical hypertension (Greenwich, Conn.)2012
A simplified mechanistic algorithm for treating resistant hypertension: efficacy in a retrospective study.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Neurogenic hypertension: pathophysiology, diagnosis and management.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Measure accurately, Act rapidly, and Partner with patients: An intuitive and practical three-part framework to guide efforts to improve hypertension control.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- American Society of Hypertension Scientific Statements Addressing Resistant Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Treatment resistant hypertension--investigation and conservative management.Deutsches Arzteblatt international · 2014Review
- Exploring issues in difficult-to-treat hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2013Review
- Improved blood pressure control in the hands of the hypertension specialist: method, magic, or something in between?Journal of clinical hypertension (Greenwich, Conn.) · 2013Article
- Psychosomatic research in hypertension: the lack of impact of decades of research and new directions to consider.Journal of clinical hypertension (Greenwich, Conn.) · 2012Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This retrospective study assessed the efficacy of a recently described, mechanism-based algorithm for treating resistant hypertension. Charts of consecutive patients seen for resistant hypertension were reviewed. Algorithm-based intervention was limited to either or both of just 2 options: (1) strengthening of the diuretic regimen, usually with addition of spironolactone; and (2) treatment with the combination of an α- + nonmetabolized β-blocker. Of 27 patients, 24 (89%) achieved control, including 13 (54%) in whom the diuretic regimen was strengthened, 6 (25%) in whom α-/β-blockade was instituted, and 5 (21%) who received both interventions. The most frequent medication adjustments were addition of a potassium-sparing diuretic in 16 (67%), doxazosin in 9 (37.5%), and replacing a metabolized with a nonmetabolized β-blocker in 6 (25%). The authors conclude that treatment based on this algorithm can both simplify and improve the management of resistant hypertension and merits further evaluation in prospective studies.
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