ArticleMolecular pain2012
Warmth suppresses and desensitizes damage-sensing ion channel TRPA1.
Article in Molecular pain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Agonism of mosquito and human transient receptor potential ankyrin 1 (TRPA1) channels by the natural drimane sesquiterpene cinnamodial.bioRxiv : the preprint server for biology · 2025Article
- Heat activation desensitizes Aedes aegypti transient receptor potential ankyrin 1 (AaTRPA1) to chemical agonists that repel mosquitoes.Pesticide biochemistry and physiology · 2025Article
- Propofol reduces human TRPA1 activity in a warm environment.Biochemistry and biophysics reports · 2025Article
- Automated thermal gradient test for unprovoked assessment of nociceptive preference in rodents.Frontiers in behavioral neuroscience · 2025Article
- TRPA1, TRPV1, and Caffeine: Pain and Analgesia.International journal of molecular sciences · 2024Review
- The Effect of Softening of Endotracheal Tubes on the Decrement of Postoperative Hoarseness and Sore Throat.Anesthesiology and pain medicine · 2022Article
- Transient receptor potential ankyrin 1 channel: An evolutionarily tuned thermosensor.Physiological research · 2021Review
- Different Therapeutic Effects of COFrontiers in neurology · 2020Article
- Phosphorylation of TRPV1 S801 Contributes to Modality-Specific Hyperalgesia in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Effects of TRPA1 activation and inhibition on TRPA1 and CGRP expression in dorsal root ganglion neurons.Neural regeneration research · 2019Article
- CaThe Journal of biological chemistry · 2017Article
- TRP Channels in Skin Biology and Pathophysiology.Pharmaceuticals (Basel, Switzerland) · 2016Review
- Article
- Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity.Scientific reports · 2016Article
- Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8.The journal of physiological sciences : JPS · 2016Article
- Taurolidine and congeners activate hTRPA1 but not hTRPV1 channels and stimulate CGRP release from mouse tracheal sensory nerves.Pharmacology research & perspectives · 2016Article
- The role of TRPA1 in muscle pain and mechanical hypersensitivity under inflammatory conditions in rats.Neuroscience · 2015Article
- Article
- Peripheral group I metabotropic glutamate receptor activation leads to muscle mechanical hyperalgesia through TRPV1 phosphorylation in the rat.The journal of pain · 2015Article
- Allyl isothiocyanate sensitizes TRPV1 to heat stimulation.Pflugers Archiv : European journal of physiology · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAcute or chronic tissue damage induces an inflammatory response accompanied by pain and alterations in local tissue temperature. Recent studies revealed that the transient receptor potential A1 (TRPA1) channel is activated by a wide variety of substances that are released following tissue damage to evoke nociception and neurogenic inflammation. Although the effects of a noxious range of cold temperatures on TRPA1 have been rigorously studied, it is not known how agonist-induced activation of TRPA1 is regulated by temperature over an innocuous range centred on the normal skin surface temperature. This study investigated the effect of temperature on agonist-induced currents in human embryonic kidney (HEK) 293 cells transfected with rat or human TRPA1 and in rat sensory neurons.
resultsAgonist-induced TRPA1 currents in HEK293 cells were strongly suppressed by warm temperatures, and almost abolished at 39°C. Such inhibition occurred when TRPA1 was activated by either electrophilic or non-electrophilic agonists. Warming not only decreased the apparent affinity of TRPA1 for mustard oil (MO), but also greatly enhanced the desensitization and tachyphylaxis of TRPA1. Warming also attenuated MO-induced ionic currents in sensory neurons. These results suggest that the extent of agonist-induced activity of TRPA1 may depend on surrounding tissue temperature, and local hyperthermia during acute inflammation could be an endogenous negative regulatory mechanism to attenuate persistent pain at the site of injury.
conclusionThese results indicate that warmth suppresses and desensitizes damage-sensing ion channel TRPA1. Such warmth-induced suppression of TRPA1 may also explain, at least in part, the mechanistic basis of heat therapy that has been widely used as a supplemental anti-nociceptive approach.
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