ArticleJournal of the American Chemical Society2012
Fluorosugar chain termination agents as probes of the sequence specificity of a carbohydrate polymerase.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 41 citations in OpenAlex.
- Synthesis of selected unnatural sugar nucleotides for biotechnological applications.Critical reviews in biotechnology · 2021Review
- Biosynthesis of Galactan inAntibiotics (Basel, Switzerland) · 2020Review
- Bacterial Cell Wall Modification with a Glycolipid Substrate.Journal of the American Chemical Society · 2019Article
- Efficient Synthesis of UDP-Furanoses via 4,5-Dicyanoimidazole(DCI)-Promoted Coupling of Furanosyl-1-Phosphates with Uridine Phosphoropiperidate.Molecules (Basel, Switzerland) · 2019Article
- Comparing Galactan Biosynthesis inThe Journal of biological chemistry · 2017Article
- Fidelity and Promiscuity of a Mycobacterial Glycosyltransferase.Journal of the American Chemical Society · 2016Article
- Polymerization-induced self-assembly of galactose-functionalized biocompatible diblock copolymers for intracellular delivery.Journal of the American Chemical Society · 2013Article
- A one-pot enzymatic approach to the O-fluoroglucoside of N-methylanthranilate.Bioorganic & medicinal chemistry · 2013Article
- Chemoenzymatic synthesis and lectin recognition of a selectively fluorinated glycoprotein.Bioorganic & medicinal chemistry · 2013Article
- Development of orally active inhibitors of protein and cellular fucosylation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Synthesis of lipid-linked arabinofuranose donors for glycosyltransferases.The Journal of organic chemistry · 2013Article
- Studies on the substrate specificity of a GDP-mannose pyrophosphorylase from Salmonella enterica.Beilstein journal of organic chemistry · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Naturally occurring carbohydrate polymers are ubiquitous. They are assembled by polymerizing glycosyltransferases, which can generate polysaccharide products with repeating sequence patterns. The fidelity of enzymes of this class is unknown. We report a method for testing the fidelity of carbohydrate polymerase pattern deposition: we synthesized fluorosugar donors and used them as chain termination agents. The requisite nucleotide fluorosugars could be produced from a single intermediate using the Jacobsen catalyst in a kinetically controlled separation of diastereomers. The resulting fluorosugar donors were used by the galactofuranosyltransferase GlfT2 from Mycobacterium tuberculosis, and the data indicate that this enzyme mediates the cell wall galactan production through a sequence-specific polymerization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.