Evidence map›Paper›PMID 22458294›Full record

ReviewOral diseases2013

The oral-systemic personalized medicine model at Marshfield Clinic.

I Glurich, A Acharya, S K Shukla, G R Nycz, M H Brilliant

Registry-linked trialAbstract readReview
In one paragraph

Review in Oral diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03641989 (Correlation Between Oral Health and Systemic Inflammation), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03641989 nacompletednot on this mapstarted 2018, after this paper: background citation

Correlation Between Oral Health and Systemic Inflammation (COHESION)

TypeinterventionalSponsorMarshfield Clinic Research FoundationRan2018 to 2019Enrolled112ConditionsInflammation, Periodontal Disease, GingivitisArmsPlaque disclosing toothpaste, Non-plaque disclosing toothpaste
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

I GlurichOffice of Scientific Writing and Publication, Marshfield, WI 54449, USA.
A Acharya
S K Shukla
G R Nycz
M H Brilliant

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
IRIS: Incorporating Research Into SightU01HG006389 · NHGRI · ESSENTIA INSTITUTE OF RURAL HEALTH · PI MCCARTY, CATHERINE ANNE · 2011 to 2014
$4.1M
NCATS NIH HHS UL1 TR000427NCRR NIH HHS 1UL1RR025011NCRR NIH HHS UL1 RR025011NHGRI NIH HHS 1U01HG006389-01NHGRI NIH HHS U01 HG006389
6 · The paper itself

Abstract

Periodontal disease and diabetes, two diseases that have achieved epidemic status, share a bidirectional relationship driven by micro-inflammatory processes. The present review frames the current understanding of the pathological processes that appear to link these diseases and advances the hypothesis that reversal of the epidemic is possible through application of interdisciplinary intervention and advancement of oral-systemic personalized medicine. An overview of how Marshfield Clinic's unique clinical, informatics and bio-repository resources and infrastructures are being aligned to advance oral-systemic personalized medicine is presented as an interventional model with the potential to reverse the epidemic trends seen for these two chronic diseases over the past several decades. The overall vision is to engineer a transformational shift in paradigm from 'personalized medicine' to 'personalized health'.

Indexed as

Precision MedicineDelivery of Health Care, IntegratedDental InformaticsDiabetes MellitusHumansMedical InformaticsMetagenomicsMicrobiotaPeriodontal DiseasesUnited StatesWisconsin

Identifiers

PMID22458294
PMCPMC3389173

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.