Evidence map›Paper›PMID 22458269›Full record

ReviewRespirology (Carlton, Vic.)2012

Translating basic science insight into public health action for multidrug- and extensively drug-resistant tuberculosis.

Nicholas D Walter, Michael Strong, Robert Belknap, Diane J Ordway, Charles L Daley, Edward D Chan

Open access · bronzeAbstract readReview
In one paragraph

Review in Respirology (Carlton, Vic.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Crystal structure of the polyketide cyclase fromActa biochimica et biophysica Sinica · 2022
    Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Nicholas D WalterDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver, Aurora, Colorado, USA. nicholas.walter@ucdenver.edu
Michael Strong
Robert Belknap
Diane J Ordway
Charles L Daley
Edward D Chan
University of Colorado Denver · USColorado State University · USDenver Public Health · USNational Jewish Health · USUniversity of Colorado Hospital · US

Funding

Immune modulation by highly virulent clinical isolates of M.tuberculosisDP2OD006450 · OD · COLORADO STATE UNIVERSITY · PI ORDWAY, DIANE JOYCE · 2009 to 2009
$2.0M
Colorado Career Development Program in the Genetics and Genomics of Lung DiseasesK12HL090147 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI GERACI, MARK W · 2007 to 2012
$2.0M
Induction of regulatory T cells by highly virulent isolates of M.tuberculosisR21AI081959 · NIAID · COLORADO STATE UNIVERSITY · PI ORDWAY, DIANE JOYCE · 2010 to 2011
$402k
NHLBI NIH HHS K12 HL090147NHLBI NIH HHS K12 HL090147-04NIAID NIH HHS R21 AI081959NIH HHS 1DP2OD006450NIH HHS DP2 OD006450
6 · The paper itself

Abstract

Multidrug (MDR)- and extensively drug-resistant (XDR) tuberculosis (TB) impose a heavy toll of human suffering and social costs. Controlling drug-resistant TB is a complex global public health challenge. Basic science advances including elucidation of the genetic basis of resistance have enabled development of new assays that are transforming the diagnosis of MDR-TB. Molecular epidemiological approaches have provided new insights into the natural history of TB with important implications for drug resistance. In the future, progress in understanding Mycobacterium tuberculosis strain-specific human immune responses, integration of systems biology approaches with traditional epidemiology and insight into the biology of mycobacterial persistence have potential to be translated into new tools for diagnosis and treatment of MDR- and XDR-TB. We review recent basic sciences developments that have contributed or may contribute to improved public health response.

Indexed as

Antitubercular AgentsDrug DiscoveryHumansPublic HealthTranslational Research, BiomedicalTreatment FailureTuberculosis, Multidrug-ResistantAntitubercular Agents

Identifiers

PMID22458269
PMCPMC4540333
OpenAlexW1569982451

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.