ArticlePloS one2012
Expression profile of nuclear receptors along male mouse nephron segments reveals a link between ERRβ and thick ascending limb function.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Circadian Clock Gene Bmal1: A Molecular Bridge from AKI to CKD.Biomolecules · 2025Review
- Current perspective on circadian function of the kidney.American journal of physiology. Renal physiology · 2024Review
- Article
- Circadian clocks of the kidney: function, mechanism, and regulation.Physiological reviews · 2022Review
- Circadian Control of Sodium and Blood Pressure Regulation.American journal of hypertension · 2021Review
- Nuclear receptors in the kidney during health and disease.Molecular aspects of medicine · 2021Review
- Effect of Hydrocortisone on Angiotensinogen (Cells · 2021Article
- Regulation of the expression of the estrogen related receptors (ERRs).Cellular and molecular life sciences : CMLS · 2020Review
- Predicted effect of circadian clock modulation of NHE3 of a proximal tubule cell on sodium transport.American journal of physiology. Renal physiology · 2018Article
- Circadian regulation of renal function.Free radical biology & medicine · 2018Review
- Altered Circadian Timing System-Mediated Non-Dipping Pattern of Blood Pressure and Associated Cardiovascular Disorders in Metabolic and Kidney Diseases.International journal of molecular sciences · 2018Review
- Comparative transcriptomic analysis identifies evolutionarily conserved gene products in the vertebrate renal distal convoluted tubule.Pflugers Archiv : European journal of physiology · 2017Article
- Sex Differences in Renal Proximal Tubular Cell Homeostasis.Journal of the American Society of Nephrology : JASN · 2016Article
- The Circadian Clock in the Regulation of Renal Rhythms.Journal of biological rhythms · 2015Review
- Molecular bases of circadian rhythmicity in renal physiology and pathology.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2013Review
- In-depth proteomic characterization of endogenous nuclear receptors in mouse liver.Molecular & cellular proteomics : MCP · 2013Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nuclear receptor family orchestrates many functions related to reproduction, development, metabolism, and adaptation to the circadian cycle. The majority of these receptors are expressed in the kidney, but their exact quantitative localization in this ultrastructured organ remains poorly described, making it difficult to elucidate the renal function of these receptors. In this report, using quantitative PCR on microdissected mouse renal tubules, we established a detailed quantitative expression map of nuclear receptors along the nephron. This map can serve to identify nuclear receptors with specific localization. Thus, we unexpectedly found that the estrogen-related receptor β (ERRβ) is expressed predominantly in the thick ascending limb (TAL) and, to a much lesser extent, in the distal convoluted tubules. In vivo treatment with an ERR inverse agonist (diethylstilbestrol) showed a link between this receptor family and the expression of the Na⁺,K⁺-2Cl⁻ cotransporter type 2 (NKCC2), and resulted in phenotype presenting some similarities with the Bartter syndrom (hypokalemia, urinary Na⁺ loss and volume contraction). Conversely, stimulation of ERRβ with a selective agonist (GSK4716) in a TAL cell line stimulated NKCC2 expression. All together, these results provide broad information regarding the renal expression of all members of the nuclear receptor family and have allowed us to identify a new regulator of ion transport in the TAL segments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.