SynthesisPloS one2012
A common SMAD7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 6 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population.Oncotarget · 2017Pooled it
- SMAD7 polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies.Oncotarget · 2016Pooled it
- A comprehensive meta-analysis of genetic associations between five key SNPs and colorectal cancer risk.Oncotarget · 2016Pooled it
- Pooled it
- Genetic variant in MTRR, but not MTR, is associated with risk of congenital heart disease: an integrated meta-analysis.PloS one · 2014Pooled it
- Pooled it
- Colorectal Cancer Risk Prediction Using the rs4939827 Polymorphism of theDiagnostics (Basel, Switzerland) · 2024Article
- Association of SMAD7 genetic markers and haplotypes with colorectal cancer risk.BMC medical genomics · 2022Article
- Single Nucleotide Polymorphism in SMAD7 and CHI3L1 and Colorectal Cancer Risk.Mediators of inflammation · 2018Review
- Common genetic variant rs3802842 in 11q23 contributes to colorectal cancer risk in Chinese population.Oncotarget · 2017Article
- Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk.European journal of human genetics : EJHG · 2016Article
- TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation.Bone research · 2015Review
- Polymorphism of SMAD7 gene (rs2337104) and risk of colorectal cancer in an Iranian population: a case-control study.Gastroenterology and hepatology from bed to bench · 2014Article
- Genome-wide association study for backfat thickness in Canchim beef cattle using Random Forest approach.BMC genetics · 2013Article
- SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population.PloS one · 2013Article
- Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry.PloS one · 2013Article
- Association of two variants in SMAD7 with the risk of congenital heart disease in the Han Chinese population.PloS one · 2013Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA common genetic variant, rs4939827, located in SMAD7, was identified by two recent genome-wide association (GWA) studies to be strongly associated with the risk of colorectal cancer (CRC). However, the following replication studies yielded conflicting results. METHOD AND
findingsWe conducted a case-control study of 641 cases and 1037 controls in a Chinese population and then performed a meta-analysis, integrating our and published data of 34313 cases and 33251 controls, to clarify the relationship between rs4939827 and CRC risk. In our case-control study, the dominant model was significant associated with increased CRC risk [Odds Ratio (OR) = 1.46; 95% confidence interval (95% CI), 1.19-1.80]. The following meta-analysis further confirmed this significant association for all genetic models but with significant between-study heterogeneity (all P for heterogeneity <0.1). By stratified analysis, we revealed that ethnicity, sample size, and tumor sites might constitute the source of heterogeneity. The cumulative analysis suggested that evident tendency to significant association was seen with adding study samples over time; whilst, sensitive analysis showed results before and after removal of each study were similar, indicating the highly stability of the current results.
conclusionResults from our case-control study and the meta-analysis collectively confirmed the significant association of the variant rs4939827 with increased risk of colorectal cancer. Nevertheless, fine-mapping of the susceptibility loci defined by rs4939287 should be imposed to reveal causal variant.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.