ArticlePloS one2012
Deregulation of sucrose-controlled translation of a bZIP-type transcription factor results in sucrose accumulation in leaves.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Identification and Characterization of theGenes · 2025Article
- cis- and trans-elements for the transcriptional regulation of sugar responsive genes: from current knowledge to future applications.Plant molecular biology · 2025Review
- Genome-wide profiling of bZIP transcription factors in Camelina sativa: implications for development and stress response.BMC genomic data · 2024Article
- Genome-Wide Analysis of C/S1-bZIP Subfamilies inInternational journal of molecular sciences · 2024Article
- Current perspectives on the regulatory mechanisms of sucrose accumulation in sugarcane.Heliyon · 2024Review
- Article
- Submergence Stress Alters the Expression of Clock Genes and Configures New Zeniths and Expression of Outputs inInternational journal of molecular sciences · 2023Article
- A petunia transcription factor,Horticulture research · 2023Article
- Overexpression of theBiology · 2023Article
- Plants utilise ancient conserved peptide upstream open reading frames in stress-responsive translational regulation.Plant, cell & environment · 2022Article
- Making Use of Plant uORFs to Control Transgene Translation in Response to Pathogen Attack.Biodesign research · 2022Article
- Key Regulators of Sucrose Metabolism Identified through Comprehensive Comparative Transcriptome Analysis in Peanuts.International journal of molecular sciences · 2021Article
- S1-bZIP Transcription Factors Play Important Roles in the Regulation of Fruit Quality and Stress Response.Frontiers in plant science · 2021Review
- Fine-tuning sugar content in strawberry.Genome biology · 2020Article
- Metabolite Control of Translation by Conserved Peptide uORFs: The Ribosome as a Metabolite Multisensor.Plant physiology · 2020Article
- Genome-wide identification and characterization of the GDP-L-galactose phosphorylase gene family in bread wheat.BMC plant biology · 2019Article
- Novel pipeline identifies new upstream ORFs and non-AUG initiating main ORFs with conserved amino acid sequences in the 5' leader of mRNAs inRNA (New York, N.Y.) · 2019Article
- The Sugar-Signaling Hub: Overview of Regulators and Interaction with the Hormonal and Metabolic Network.International journal of molecular sciences · 2018Review
- The wheat TabZIP2 transcription factor is activated by the nutrient starvation-responsive SnRK3/CIPK protein kinase.Plant molecular biology · 2018Article
- The common transcriptional subnetworks of the grape berry skin in the late stages of ripening.BMC plant biology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sucrose is known to repress the translation of Arabidopsis thaliana AtbZIP11 transcript which encodes a protein belonging to the group of S (S--stands for small) basic region-leucine zipper (bZIP)-type transcription factor. This repression is called sucrose-induced repression of translation (SIRT). It is mediated through the sucrose-controlled upstream open reading frame (SC-uORF) found in the AtbZIP11 transcript. The SIRT is reported for 4 other genes belonging to the group of S bZIP in Arabidopsis. Tobacco tbz17 is phylogenetically closely related to AtbZIP11 and carries a putative SC-uORF in its 5'-leader region. Here we demonstrate that tbz17 exhibits SIRT mediated by its SC-uORF in a manner similar to genes belonging to the S bZIP group of the Arabidopsis genus. Furthermore, constitutive transgenic expression of tbz17 lacking its 5'-leader region containing the SC-uORF leads to production of tobacco plants with thicker leaves composed of enlarged cells with 3-4 times higher sucrose content compared to wild type plants. Our finding provides a novel strategy to generate plants with high sucrose content.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.