ArticleFrontiers in pharmacology2012
Physiological antioxidative network of the bilirubin system in aging and age-related diseases.
Article in Frontiers in pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
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- The predictive potential and relationship of peripheral non-enzymatic antioxidants with clinical symptoms in first-episode male adolescent-onset schizophrenia patients.Annals of general psychiatry · 2026Article
- METABOLOMIC SIGNATURES OF EXTREME OLD AGE: FINDINGS FROM THE NEW ENGLAND CENTENARIAN STUDY.bioRxiv : the preprint server for biology · 2025Article
- Open-Chain Tetrapyrroles Meet Metal Ions in the Functional Molecular Material Science.ChemPlusChem · 2025Article
- Endogenous and Exogenous Antioxidants as Agents Preventing the Negative Effects of Contrast Media (Contrast-Induced Nephropathy).Pharmaceuticals (Basel, Switzerland) · 2023Review
- The J-shape Association between Total Bilirubin and Stroke in Older Patients with Obstructive Sleep Apnea Syndrome: A Multicenter Study.The journal of nutrition, health & aging · 2023Article
- DPP9 as a Potential Novel Mediator in Gastrointestinal Virus Infection.Antioxidants (Basel, Switzerland) · 2022Article
- Relationship between serum indirect bilirubin and prostate volume in patients with benign prostatic hyperplasia: a cross-sectional study.Annals of translational medicine · 2022Article
- Evaluation of Antioxidative and Neuroprotective Activities of Total Flavonoids From Sea Buckthorn (Frontiers in nutrition · 2022Article
- Activation of whole body by high levels of polyamine intake in rats.Amino acids · 2021Article
- Low Albumin, Low Bilirubin, and High Alfa-Fetoprotein Are Associated with a Rapid Renal Function Decline in a Large Population Follow-Up Study.Journal of personalized medicine · 2021Article
- Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids.American journal of physiology. Cell physiology · 2021Review
- Can bilirubin nanomedicine become a hope for the management of COVID-19?Medical hypotheses · 2021Article
- Bardoxolone-Methyl (CDDO-Me) Impairs Tumor Growth and Induces Radiosensitization of Oral Squamous Cell Carcinoma Cells.Frontiers in pharmacology · 2020Article
- Anti-Wrinkling and Anti-Melanogenic Effect ofInternational journal of molecular sciences · 2019Article
- The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in Alzheimer's Disease.Journal of clinical medicine · 2017Review
- Bilirubin provides perforator flap protection from ischaemia-reperfusion injury in a rat model: a preliminary result.International wound journal · 2016Article
- Chemical and Physical Approaches to Extend the Replicative and Differentiation Potential of Stem Cells.Stem cell reviews and reports · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress is detrimental to life process and is particularly responsible for aging and age-related diseases. Thus, most organisms are well equipped with a spectrum of biological defense mechanisms against oxidative stress. The major efficient antioxidative mechanism is the glutathione system, operating a redox cycling mechanism for glutathione utilization, which consists of glutathione and its peroxidase and reductase. However, this system is mainly effective for hydrophilic oxidants, while lipophilic oxidants require another scavenging system. Since many age-related pathological conditions are related to lipid peroxidation, especially in association with the aging process, the physiological role of the scavenging system for lipophilic oxidants should be considered. In this regard, the biliverdin to bilirubin conversion pathway, via biliverdin reductase (BVR), is suggested to be another major protective mechanism that scavenges lipophilic oxidants because of the lipophilic nature of bilirubin. The efficiency of this bilirubin system might be potentiated by operation of the intertwined bicyclic systems of the suggested redox metabolic cycle of biliverdin and bilirubin and the interactive control cycle of BVR and heme oxygenase. In order to combat oxidative stress, both antioxidative systems against hydrophilic and lipophilic oxidants are required to work cooperatively. In this regard, the roles of the bilirubin system in aging and age-related diseases are reassessed in this review, and their interacting networks are evaluated.
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