ArticlePLoS genetics2012
Cis-by-Trans regulatory divergence causes the asymmetric lethal effects of an ancestral hybrid incompatibility gene.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 37 citations in OpenAlex.
- Expression pattern of resynthesized allotetraploid Capsella is determined by hybridization, not whole-genome duplication.The New phytologist · 2023Article
- System drift and speciation.Evolution; international journal of organic evolution · 2022Article
- The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila.PLoS genetics · 2021Article
- Drosophila Satellite Repeats at the Intersection of Chromatin, Gene Regulation and Evolution.Progress in molecular and subcellular biology · 2021Article
- Ecological divergence in sympatry causes gene misexpression in hybrids.Molecular ecology · 2020Article
- Adaptive evolution among cytoplasmic piRNA proteins leads to decreased genomic auto-immunity.PLoS genetics · 2020Article
- A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation.Nucleic acids research · 2020Article
- The subgenomes show asymmetric expression of alleles in hybrid lineages ofGenome research · 2019Article
- Support for the Dominance Theory inGenetics · 2018Article
- The Hybrid Incompatibility GenesGenetics · 2017Article
- Ectopic application of the repressive histone modification H3K9me2 establishes post-zygotic reproductive isolation inGenes & development · 2017Article
- Article
- Gene Regulation and Speciation.Trends in genetics : TIG · 2017Review
- The Drosophila bag of marbles Gene Interacts Genetically with Wolbachia and Shows Female-Specific Effects of Divergence.PLoS genetics · 2015Article
- Hybrid incompatibility despite pleiotropic constraint in a sequence-based bioenergetic model of transcription factor binding.Genetics · 2014Article
- Hybrid incompatibility arises in a sequence-based bioenergetic model of transcription factor binding.Genetics · 2014Article
- A screen for F1 hybrid male rescue reveals no major-effect hybrid lethality loci in the Drosophila melanogaster autosomal genome.G3 (Bethesda, Md.) · 2014Article
- Heterochronic meiotic misexpression in an interspecific yeast hybrid.Molecular biology and evolution · 2014Article
- Tempo and mode of regulatory evolution in Drosophila.Genome research · 2014Article
- The Hmr and Lhr hybrid incompatibility genes suppress a broad range of heterochromatic repeats.PLoS genetics · 2014Article
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2 authors at 1 institution in 1 country.
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Abstract
The Dobzhansky and Muller (D-M) model explains the evolution of hybrid incompatibility (HI) through the interaction between lineage-specific derived alleles at two or more loci. In agreement with the expectation that HI results from functional divergence, many protein-coding genes that contribute to incompatibilities between species show signatures of adaptive evolution, including Lhr, which encodes a heterochromatin protein whose amino acid sequence has diverged extensively between Drosophila melanogaster and D. simulans by natural selection. The lethality of D. melanogaster/D. simulans F1 hybrid sons is rescued by removing D. simulans Lhr, but not D. melanogaster Lhr, suggesting that the lethal effect results from adaptive evolution in the D. simulans lineage. It has been proposed that adaptive protein divergence in Lhr reflects antagonistic coevolution with species-specific heterochromatin sequences and that defects in LHR protein localization cause hybrid lethality. Here we present surprising results that are inconsistent with this coding-sequence-based model. Using Lhr transgenes expressed under native conditions, we find no evidence that LHR localization differs between D. melanogaster and D. simulans, nor do we find evidence that it mislocalizes in their interspecific hybrids. Rather, we demonstrate that Lhr orthologs are differentially expressed in the hybrid background, with the levels of D. simulans Lhr double that of D. melanogaster Lhr. We further show that this asymmetric expression is caused by cis-by-trans regulatory divergence of Lhr. Therefore, the non-equivalent hybrid lethal effects of Lhr orthologs can be explained by asymmetric expression of a molecular function that is shared by both orthologs and thus was presumably inherited from the ancestral allele of Lhr. We present a model whereby hybrid lethality occurs by the interaction between evolutionarily ancestral and derived alleles.
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