ArticlePLoS genetics2012
Contrasted patterns of molecular evolution in dominant and recessive self-incompatibility haplotypes in Arabidopsis.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 92 citations in OpenAlex.
- Genomic analysis of 3,330 accessions provides insights into the evolutionary history and self-incompatibility locus of the Brassica A genome.Nature genetics · 2026Article
- Dominance modifiers at the Arabidopsis self-incompatibility locus retain proto-miRNA features and act through non-canonical pathways.PLoS genetics · 2026Article
- Genomic implications of the repeated shift to self-fertilization across a species' geographic distribution.The Journal of heredity · 2025Article
- The genetic architecture of the load linked to dominant and recessive self-incompatibility alleles ineLife · 2024Article
- Transposable elements cause the loss of self-incompatibility in citrus.Plant biotechnology journal · 2024Article
- Stop and go signals at the stigma-pollen interface of the Brassicaceae.Plant physiology · 2023Article
- Transition to Self-compatibility Associated With Dominant S-allele in a Diploid Siberian Progenitor of Allotetraploid Arabidopsis kamchatica Revealed by Arabidopsis lyrata Genomes.Molecular biology and evolution · 2023Article
- Ancestral self-compatibility facilitates the establishment of allopolyploids in Brassicaceae.Plant reproduction · 2023Review
- Stepwise recombination suppression around the mating-type locus in an ascomycete fungus with self-fertile spores.PLoS genetics · 2023Article
- Flower transcriptional response to long term hot and cold environments inFrontiers in plant science · 2023Article
- Comprehensive computational analysis of the SRK-SP11 molecular interaction underlying self-incompatibility in Brassicaceae using improved structure prediction for cysteine-rich proteins.Computational and structural biotechnology journal · 2023Article
- Autophagy is required for self-incompatible pollen rejection in two transgenic Arabidopsis thaliana accessions.Plant physiology · 2022Article
- Whole-genome sequencing and genome regions of special interest: Lessons from major histocompatibility complex, sex determination, and plant self-incompatibility.Molecular ecology · 2021Article
- Homology-Based Interactions between Small RNAs and Their Targets Control Dominance Hierarchy of Male Determinant Alleles of Self-Incompatibility inInternational journal of molecular sciences · 2021Article
- Inversion breakpoints and the evolution of supergenes.Molecular ecology · 2021Review
- Drivers of linkage disequilibrium across a species' geographic range.PLoS genetics · 2021Article
- Evolution of self-incompatibility in the Brassicaceae: Lessons from a textbook example of natural selection.Evolutionary applications · 2020Article
- Base-Pairing Requirements for Small RNA-Mediated Gene Silencing of Recessive Self-Incompatibility Alleles inGenetics · 2020Article
- Generation of Transgenic Self-IncompatiblePlants (Basel, Switzerland) · 2019Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-incompatibility has been considered by geneticists a model system for reproductive biology and balancing selection, but our understanding of the genetic basis and evolution of this molecular lock-and-key system has remained limited by the extreme level of sequence divergence among haplotypes, resulting in a lack of appropriate genomic sequences. In this study, we report and analyze the full sequence of eleven distinct haplotypes of the self-incompatibility locus (S-locus) in two closely related Arabidopsis species, obtained from individual BAC libraries. We use this extensive dataset to highlight sharply contrasted patterns of molecular evolution of each of the two genes controlling self-incompatibility themselves, as well as of the genomic region surrounding them. We find strong collinearity of the flanking regions among haplotypes on each side of the S-locus together with high levels of sequence similarity. In contrast, the S-locus region itself shows spectacularly deep gene genealogies, high variability in size and gene organization, as well as complete absence of sequence similarity in intergenic sequences and striking accumulation of transposable elements. Of particular interest, we demonstrate that dominant and recessive S-haplotypes experience sharply contrasted patterns of molecular evolution. Indeed, dominant haplotypes exhibit larger size and a much higher density of transposable elements, being matched only by that in the centromere. Overall, these properties highlight that the S-locus presents many striking similarities with other regions involved in the determination of mating-types, such as sex chromosomes in animals or in plants, or the mating-type locus in fungi and green algae.
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