ArticleJournal of virology2012
Identical consensus sequence and conserved genomic polymorphism of hepatitis E virus during controlled interspecies transmission.
Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Three Distinct Reporter Systems of Hepatitis E Virus and Their Utility as Drug Screening Platforms.Viruses · 2023Review
- Identification of interferon-stimulated genes with modulated expression during hepatitis E virus infection in pig liver tissues and human HepaRG cells.Frontiers in immunology · 2023Article
- HEV Cell Culture.Advances in experimental medicine and biology · 2023Article
- Development of Recombinant Infectious Hepatitis E Virus Harboring the nanoKAZ Gene and Its Application in Drug Screening.Journal of virology · 2022Article
- Characterization of a Cell Culture System of Persistent Hepatitis E Virus Infection in the Human HepaRG Hepatic Cell Line.Viruses · 2021Article
- Phylogenetic analysis of two new complete genomes of the hepatitis E virus (HEV) genotype 3 from Thailand.Molecular biology reports · 2020Article
- Prevalence and phylogenetic analysis of hepatitis E virus in pigs in Vietnam.BMC veterinary research · 2020Article
- Hepatitis E virus infection during pregnancy.Virology journal · 2020Review
- High Hepatitis E virus (HEV) Positivity Among Domestic Pigs and Risk of HEV Infection of Individuals Occupationally Exposed to Pigs and Pork Meat in Hanoi, Vietnam.Open forum infectious diseases · 2019Article
- Public health risks associated with hepatitis E virus (HEV) as a food-borne pathogen.EFSA journal. European Food Safety Authority · 2017Article
- Hepatitis E Virus Genotypes and Evolution: Emergence of Camel Hepatitis E Variants.International journal of molecular sciences · 2017Review
- Review
- The high prevalence of hepatitis E virus infection in wild boars in Ibaraki Prefecture, Japan.The Journal of veterinary medical science · 2016Article
- Quantitative proteomics identifies host factors modulated during acute hepatitis E virus infection in the swine model.Journal of virology · 2015Article
- Characterization of the polyproline region of the hepatitis E virus in immunocompromised patients.Journal of virology · 2014Article
- Seroprevalence and evolutionary dynamics of genotype 4 hepatitis E virus in Shandong Province, China.World journal of gastroenterology · 2014Observational
- Genetic host specificity of hepatitis E virus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014Article
- Full-length sequence analysis of hepatitis E virus isolates: showing potential determinants of virus genotype and identity.Virus genes · 2013Article
- Transmission of hepatitis E virus from rabbits to cynomolgus macaques.Emerging infectious diseases · 2013Article
- Evolution of the hepatitis E virus hypervariable region.The Journal of general virology · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-throughput sequencing of bile and feces from two pigs experimentally infected with human hepatitis E virus (HEV) of genotype 3f revealed the same full-length consensus sequence as in the human sample. Twenty-nine percent of polymorphic sites found in HEV from the human sample were conserved throughout the infection of the heterologous host. The interspecies transmission of HEV quasispecies is the result of a genomic negative-selection pressure on random mutations which can be deleterious to the viral population. HEV intrahost nucleotide diversity was found to be in the lower range of other human RNA viruses but correlated with values found for zoonotic viruses. HEV transmission between humans and pigs does not seem to be modulated by host-specific mutations, suggesting that adaptation is mainly regulated by ecological drivers.
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