ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
A Drosophila DEG/ENaC subunit functions specifically in gustatory neurons required for male courtship behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53 citing papers in PubMed, 88 citations in OpenAlex.
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- Harnessing Insect Chemosensory and Mechanosensory Receptors Involved in Feeding for Precision Pest Management.Life (Basel, Switzerland) · 2025Review
- Function and evolution of Ir52 receptors in mate detection in Drosophila.Current biology : CB · 2024Article
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- A modular circuit architecture coordinates the diversification of courtship strategies inbioRxiv : the preprint server for biology · 2023Article
- Social experience and pheromone receptor activity reprogram gene expression in sensory neurons.G3 (Bethesda, Md.) · 2023Article
- A single-cell atlas of the sexually dimorphic Drosophila foreleg and its sensory organs during development.PLoS biology · 2023Article
- The diverse functions of the DEG/ENaC family: linking genetic and physiological insights.The Journal of physiology · 2023Article
- Gustation in insects: taste qualities and types of evidence used to show taste function of specific body parts.Journal of insect science (Online) · 2023Article
- Understanding the impact of sociosexual interactions on sleep usingFrontiers in physiology · 2023Article
- A neurogenetic mechanism of experience-dependent suppression of aggression.Science advances · 2022Article
- Review
- DEG/ENaC Ion Channels in the Function of the Nervous System: From Worm to Man.Advances in experimental medicine and biology · 2021Article
- Functional properties of insect olfactory receptors: ionotropic receptors and odorant receptors.Cell and tissue research · 2021Review
- Distinct Roles and Synergistic Function of FruCell reports · 2020Article
- Molecular mechanisms of olfactory detection in insects: beyond receptors.Open biology · 2020Article
- Neuronal Compartmentalization: A Means to Integrate Sensory Input at the Earliest Stage of Information Processing?BioEssays : news and reviews in molecular, cellular and developmental biology · 2020Article
- Article
- Contact-Chemosensory Evolution Underlying Reproductive Isolation inFrontiers in behavioral neuroscience · 2020Review
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6 authors at 2 institutions in 1 country.
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Abstract
Detection of specific female pheromones stimulates courtship behavior in Drosophila melanogaster males, but the chemosensory molecules, cells, and mechanisms involved remain poorly understood. Here we show that ppk25, a DEG/ENaC ion channel subunit required for normal male response to females, is expressed at highest levels in a single sexually dimorphic gustatory neuron of most taste hairs on legs and wings, but not in neurons that detect courtship-inhibiting pheromones or food. Synaptic inactivation of ppk25-expressing neurons, or knockdown of ppk25 expression in all gustatory neurons, significantly impairs male response to females, whereas gustatory expression of ppk25 rescues the courtship behavior of ppk25 mutant males. Remarkably, the only other detectable albeit significantly weaker expression of ppk25 occurs in olfactory neurons implicated in modulation of courtship behavior. However, expression of ppk25 in olfactory neurons is not required for male courtship under our experimental conditions. These data show that ppk25 functions specifically in peripheral taste neurons involved in activation of courtship behavior, an unexpected function for this type of channel. Furthermore, our work identifies a small subset of gustatory neurons with an essential role in activation of male courtship behavior, most likely in response to female pheromones.
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