ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Push-pull control of motor output.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Probabilistic inference of homonymous and heteronymous recurrent inhibition in human muscles from large-scale motor neuron recordings.Science advances · 2026Article
- Automating population construction and parallel simulation of biophysical models for neuromuscular cells: An inverse approach.PLoS computational biology · 2026Article
- The modulation of human motoneuron discharge patterns with contraction force in resistance- and endurance-trained individuals.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Tonically active interneurons gate motor output inbioRxiv : the preprint server for biology · 2026Article
- Circuit logic of oxytocin and vasopressin complementary actions.Frontiers in neuroscience · 2026Review
- Bed rest and endurance retraining alter persistent inward current estimates in young and older males.Frontiers in physiology · 2026Article
- Intrinsic properties of spinal motoneurons degrade ankle torque control in humans.The Journal of physiology · 2025Article
- Motor cortical inactivation impairs corrective submovements in mice performing a hold-still center-out reach task.Journal of neurophysiology · 2024Article
- Mechanisms of Hebbian-like plasticity in the ventral premotor - primary motor network.The Journal of physiology · 2023Article
- Short-latency stretch reflexes depend on the balance of activity in agonist and antagonist muscles during ballistic elbow movements.Journal of neurophysiology · 2023Article
- GABAergic Mechanisms Can Redress the Tilted Balance between Excitation and Inhibition in Damaged Spinal Networks.Molecular neurobiology · 2021Review
- Neuronal Circuits That Control Rhythmic Pectoral Fin Movements in Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Estimates of persistent inward current in human motor neurons during postural sway.Journal of neurophysiology · 2019Article
- Risk-taking bias in human decision-making is encoded via a right-left brain push-pull system.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Optimal synaptic signaling connectome for locomotory behavior in Caenorhabditis elegans: Design minimizing energy cost.PLoS computational biology · 2017Article
- The potential for understanding the synaptic organization of human motor commands via the firing patterns of motoneurons.Journal of neurophysiology · 2017Review
- Synaptic control of the shape of the motoneuron pool input-output function.Journal of neurophysiology · 2017Article
- A genetically defined asymmetry underlies the inhibitory control of flexor-extensor locomotor movements.eLife · 2015Article
- Cadence-dependent changes in corticospinal excitability of the biceps brachii during arm cycling.Journal of neurophysiology · 2015Article
- The optimal neural strategy for a stable motor task requires a compromise between level of muscle cocontraction and synaptic gain of afferent feedback.Journal of neurophysiology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
Inhibition usually decreases input-output excitability of neurons. If, however, inhibition is coupled to excitation in a push-pull fashion, where inhibition decreases as excitation increases, neuron excitability can be increased. Although the presence of push-pull organization has been demonstrated in single cells, its functional impact on neural processing depends on its effect on the system level. We studied push-pull in the motor output stage of the feline spinal cord, a system that allows independent control of inhibitory and excitatory components. Push-pull organization was clearly present in ankle extensor motoneurons, producing increased peak-to-peak modulation of synaptic currents. The effect at the system level was equally strong. Independent control of the inhibitory component showed that the stronger the background of inhibition, the greater the peak force production. This illustrates the paradox at the heart of push-pull organization: increased force output can be achieved by increasing background inhibition to provide greater disinhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.