ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
The mode of retinal presynaptic inhibition switches with light intensity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Long-distance object motion evokes direction selectivity in retinal neurons through nicotinic receptors in bipolar cells.Journal of neurophysiology · 2026Article
- Rod photoreceptors control the ON vs OFF polarity of cone-signaling neurons.Communications biology · 2026Article
- Decoding the roles of bipolar, amacrine, and horizontal cells.Handbook of clinical neurology · 2026Review
- Cholinergic feedback to bipolar cells contributes to motion detection in the mouse retina.Cell reports · 2021Article
- EAAT5 Glutamate Transporter-Mediated Inhibition in the Vertebrate Retina.Frontiers in cellular neuroscience · 2021Review
- Light-evoked glutamate transporter EAAT5 activation coordinates with conventional feedback inhibition to control rod bipolar cell output.Journal of neurophysiology · 2020Article
- Dopaminergic Modulation of Signal Processing in a Subset of Retinal Bipolar Cells.Frontiers in cellular neuroscience · 2020Article
- Bipolar Cell Type-Specific Expression and Conductance of Alpha-7 Nicotinic Acetylcholine Receptors in the Mouse Retina.Investigative ophthalmology & visual science · 2019Article
- Extrasynaptic NMDA Receptors on Rod Pathway Amacrine Cells: Molecular Composition, Activation, and Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina.Physiological reports · 2018Article
- Dopamine D1 receptor activation contributes to light-adapted changes in retinal inhibition to rod bipolar cells.Journal of neurophysiology · 2018Article
- Morphological and physiological analysis of type-5 and other bipolar cells in the Mouse Retina.Neuroscience · 2016Article
- Differential signalling and glutamate receptor compositions in the OFF bipolar cell types in the mouse retina.The Journal of physiology · 2016Article
- Glutamatergic Retinal Waves.Frontiers in neural circuits · 2016Review
- Differential encoding of spatial information among retinal on cone bipolar cells.Journal of neurophysiology · 2015Article
- Ambient illumination switches contrast preference of specific retinal processing streams.Journal of neurophysiology · 2015Article
- Recording light-evoked postsynaptic responses in neurons in dark-adapted, mouse retinal slice preparations using patch clamp techniques.Journal of visualized experiments : JoVE · 2015Article
- Marking cells with infrared fluorescent proteins to preserve photoresponsiveness in the retina.BioTechniques · 2014Article
- Presynaptic inhibition by α2 receptor/adenylate cyclase/PDE4 complex at retinal rod bipolar synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Post-receptor adaptation: lighting up the details.Current biology : CB · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Excitatory amino acid transporters (EAATs) terminate signaling in the CNS by clearing released glutamate. Glutamate also evokes an EAAT-mediated Cl(-) current, but its role in CNS signaling is poorly understood. We show in mouse retina that EAAT-mediated Cl(-) currents that were evoked by light inhibit rod pathway signaling. EAATs reside on rod bipolar cell axon terminals where GABA and glycine receptors also mediate light-evoked inhibition. We found that the mode of inhibition depended on light intensity. Dim light evoked GABAergic and glycinergic inhibition with rapid kinetics and a large spatial extent. Bright light evoked predominantly EAAT-mediated inhibition with slow kinetics and a small spatial extent. The switch to EAAT-mediated signaling in bright light supplements receptor-mediated signaling to expand the dynamic range of inhibition and contributes to the transition from rod to cone signaling by suppressing rod pathway signaling in bright light conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.