ArticlePlant physiology2012
Evolution of a complex disease resistance gene cluster in diploid Phaseolus and tetraploid Glycine.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 70 citations in OpenAlex.
- Dissection of local haplotype diversity at soybean rust loci reveals resistance-associated and context-dependent variation patterns in diverse germplasm.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Fine-mapping, candidate gene identification, and marker development for the apple scab resistance gene Rvi2.Journal of experimental botany · 2026Article
- Applications of the Soybean Expression Atlas in Genomics and Transcriptomics Research.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Chromosome-level genome assembly and annotation of Ulmus minor reveal dynamic intrageneric clusters of resistance genes.The plant genome · 2025Article
- Diploidization in a wild rice allopolyploid is both episodic and gradual.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A comprehensive review of soybean RNL and TIR domain proteins.Plant molecular biology · 2024Review
- Defining genomic landscape for identification of potential candidate resistance genes associated with major rice diseases through MetaQTL analysis.Journal of biosciences · 2024Article
- Comparison ofFrontiers in plant science · 2024Article
- Comparative analysis of soybean transcriptional profiles reveals defense mechanisms involved in resistance against Diaporthe caulivora.Scientific reports · 2023Article
- Investigation of NLR Genes Reveals Divergent Evolution on NLRome in Diploid and Polyploid Species in GenusGenes · 2023Article
- Article
- Meta-analysis reveals consensus genomic regions associated with multiple disease resistance in wheat (Molecular breeding : new strategies in plant improvement · 2022Article
- A CRISPR/Cas12a-based portable platform for rapid detection ofFrontiers in plant science · 2022Article
- Engineering crops of the future: CRISPR approaches to develop climate-resilient and disease-resistant plants.Genome biology · 2020Review
- Genome-Wide Identification and Evolutionary Analysis ofFrontiers in genetics · 2020Article
- Molecular dissection of resistance gene cluster and candidate gene identification of PlScientific reports · 2019Article
- An evolutionarily conserved non-synonymous SNP in a leucine-rich repeat domain determines anthracnose resistance in watermelon.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- Article
- Genotypes and Genomic Regions Associated WithFrontiers in plant science · 2019Article
- Genomic and epigenomic immunity in common bean: the unusual features of NB-LRR gene family.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 7 institutions in 2 countries.
Funding
Abstract
We used a comparative genomics approach to investigate the evolution of a complex nucleotide-binding (NB)-leucine-rich repeat (LRR) gene cluster found in soybean (Glycine max) and common bean (Phaseolus vulgaris) that is associated with several disease resistance (R) genes of known function, including Rpg1b (for Resistance to Pseudomonas glycinea1b), an R gene effective against specific races of bacterial blight. Analysis of domains revealed that the amino-terminal coiled-coil (CC) domain, central nucleotide-binding domain (NB-ARC [for APAF1, Resistance genes, and CED4]), and carboxyl-terminal LRR domain have undergone distinct evolutionary paths. Sequence exchanges within the NB-ARC domain were rare. In contrast, interparalogue exchanges involving the CC and LRR domains were common, consistent with both of these regions coevolving with pathogens. Residues under positive selection were overrepresented within the predicted solvent-exposed face of the LRR domain, although several also were detected within the CC and NB-ARC domains. Superimposition of these latter residues onto predicted tertiary structures revealed that the majority are located on the surface, suggestive of a role in interactions with other domains or proteins. Following polyploidy in the Glycine lineage, NB-LRR genes have been preferentially lost from one of the duplicated chromosomes (homeologues found in soybean), and there has been partitioning of NB-LRR clades between the two homeologues. The single orthologous region in common bean contains approximately the same number of paralogues as found in the two soybean homeologues combined. We conclude that while polyploidization in Glycine has not driven a stable increase in family size for NB-LRR genes, it has generated two recombinationally isolated clusters, one of which appears to be in the process of decay.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.