Evidence map›Paper›PMID 22457397›Full record

SynthesisThe Journal of nutrition2012

The effects of fructose intake on serum uric acid vary among controlled dietary trials.

D David Wang, John L Sievenpiper, Russell J de Souza, Laura Chiavaroli, Vanessa Ha, Adrian I Cozma, Arash Mirrahimi, Matthew E Yu, Amanda J Carleton, Marco Di Buono and 6 more

4 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 85 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 12 pooled it
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01363791 unknown statusnot on this map

Effect of Fructose on Metabolic Control in Humans: A Series of Systematic Reviews and Meta-analyses to Provide Evidence-based Guidance for Nutrition Guidelines Development

TypeobservationalSponsorJohn SievenpiperRan2009 to 2016Enrolled1ConditionsDyslipidemia, Diabetes, Prediabetes, DysglycemiaArmsDietary fructose
NCT01608607 unknown statusnot on this map

Effect of Fructose-containing Sugar Sweetened Beverages (SSBs) on Body Weight: A Systematic Review and Meta-analysis of Controlled Feeding Trials to Provide Evidence-based Guidance for Nutrition Guidelines Development

TypeobservationalSponsorJohn SievenpiperRan2012 to 2015Enrolled1ConditionsOverweight, Obesity, Diabetes, PrediabetesArmsFructose-containing sugar sweetened beverages
NCT01608620 unknown statusnot on this map

The Relation of Total and Individual Fructose-containing Sugars With Incident Cardiometabolic Diseases: A Series of Systematic Reviews and Meta-analyses of Prospective Observational Studies

TypeobservationalSponsorJohn SievenpiperRan2012 to 2016Enrolled1ConditionsOverweight, Obesity, Dyslipidemia, Hyperlipidemia
NCT02716870 unknown statusnot on this mapstarted 2015, after this paper: background citation

Effect of Important Food Sources of Fructose-containing Sugars on Cardiometabolic Risk Factors: A Series of Systematic Reviews and Meta-analyses of Controlled Trials to Inform Dietary Guidelines, Public Health Policy, and Future Trial Design

TypeobservationalSponsorUniversity of TorontoRan2015 to 2020Enrolled1ConditionsDyslipidemia, Diabetes, Prediabetes, DysglycemiaArmsFructose-containing Sugars
3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 12 syntheses or guidelines pooled it, 215 citations in OpenAlex.

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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 4 countries.

D David WangClinical Nutrition and Risk Factor Modification Centre, St. Michael’s Hospital, Toronto, ON, Canada.
John L Sievenpiper
Russell J de Souza
Laura Chiavaroli
Vanessa Ha
Adrian I Cozma
Arash Mirrahimi
Matthew E Yu
Amanda J Carleton
Marco Di Buono
Alexandra L Jenkins
Lawrence A Leiter
Thomas M S Wolever
Joseph Beyene
Cyril W C Kendall
David J A Jenkins
St. Michael's Hospital · CAHeart and Stroke Foundation · CAUniversity of Toronto · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

Hyperuricemia is linked to gout and features of metabolic syndrome. There is concern that dietary fructose may increase uric acid concentrations. To assess the effects of fructose on serum uric acid concentrations in people with and without diabetes, we conducted a systematic review and meta-analysis of controlled feeding trials. We searched MEDLINE, EMBASE, and the Cochrane Library for relevant trials (through August 19, 2011). Analyses included all controlled feeding trials ≥ 7 d investigating the effect of fructose feeding on uric acid under isocaloric conditions, where fructose was isocalorically exchanged with other carbohydrate, or hypercaloric conditions, and where a control diet was supplemented with excess energy from fructose. Data were aggregated by the generic inverse variance method using random effects models and expressed as mean difference (MD) with 95% CI. Heterogeneity was assessed by the Q statistic and quantified by I(2). A total of 21 trials in 425 participants met the eligibility criteria. Isocaloric exchange of fructose for other carbohydrate did not affect serum uric acid in diabetic and nondiabetic participants [MD = 0.56 μmol/L (95% CI: -6.62, 7.74)], with no evidence of inter-study heterogeneity. Hypercaloric supplementation of control diets with fructose (+35% excess energy) at extreme doses (213-219 g/d) significantly increased serum uric acid compared with the control diets alone in nondiabetic participants [MD = 31.0 mmol/L (95% CI: 15.4, 46.5)] with no evidence of heterogeneity. Confounding from excess energy cannot be ruled out in the hypercaloric trials. These analyses do not support a uric acid-increasing effect of isocaloric fructose intake in nondiabetic and diabetic participants. Hypercaloric fructose intake may, however, increase uric acid concentrations. The effect of the interaction of energy and fructose remains unclear. Larger, well-designed trials of fructose feeding at "real world" doses are needed.

Indexed as

Clinical Trials as TopicDiet, DiabeticEnergy MetabolismFructoseHumansHyperuricemiaMetabolic SyndromeUric AcidFructoseUric Acid

Identifiers

PMID22457397
PMCPMC3327749
OpenAlexW2168068636

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.