ReviewCurrent hypertension reports2012
Carotid baroreceptor activation for the treatment of resistant hypertension and heart failure.
Review in Current hypertension reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Prognostic Implications of Orthostatic Hypotension in Elective Coronary Artery Bypass Grafting.Medical science monitor : international medical journal of experimental and clinical research · 2025Observational
- Potential Neuromodulation of the Cardio-Renal Syndrome.Journal of clinical medicine · 2023Review
- Carotid sinus nerve stimulation attenuates alveolar bone loss and inflammation in experimental periodontitis.Scientific reports · 2020Article
- Feasibility of kilohertz frequency alternating current neuromodulation of carotid sinus nerve activity in the pig.Scientific reports · 2019Article
- Cardiac innervation and sudden cardiac death.Circulation research · 2015Review
- Non-interventional management of resistant hypertension.World journal of cardiology · 2014Review
- Treatment resistant hypertension--investigation and conservative management.Deutsches Arzteblatt international · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carotid baroreceptors play an important role in blood pressure regulation through modification of sympathetic nervous activity. Conditions associated with increased sympathetic activity, such as resistant hypertension and heart failure, represent potential targets for carotid baroreceptor activation. Recent technological advances made available a small device, like a pacemaker, that constantly activates carotid baroreceptors. Primary experimental and clinical data obtained from use of this device point toward significant blood pressure reduction in patients with resistant hypertension, as well as beneficial effects on cardiac structure and function. A large feasibility trial revealed promising results; however, the first randomized study in patients with resistant hypertension raised several concerns regarding the efficacy and safety of baroreceptor activation with the device. This review critically evaluates available data obtained with carotid baroreceptor activation, emphasizing data acquired during the past year, and discusses the advantages and disadvantages as well as the future prospects of this intervention.
Indexed as
Identifiers
22457242What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.