ArticleDiabetes care2012
Estimating hepatic glucokinase activity using a simple model of lactate kinetics.
Article in Diabetes care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Hepatic Glucose Uptake During Euglycemic Hyperinsulinemia Associates With Glycemia During Oral Glucose Tolerance Test.Journal of the Endocrine Society · 2025Article
- A New Oral Model to Assess Postprandial Lactate Production Rate.IEEE transactions on bio-medical engineering · 2022Article
- Origins and History of the Minimal Model of Glucose Regulation.Frontiers in endocrinology · 2020Article
- Novel aspects of the role of the liver in carbohydrate metabolism.Metabolism: clinical and experimental · 2019Review
- Peripheral Mechanisms Mediating the Sustained Antidiabetic Action of FGF1 in the Brain.Diabetes · 2019Article
- Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia.Scientific reports · 2018Article
- Quantitative path to deep phenotyping: Possible importance of reduced hepatic insulin degradation to type 2 diabetes mellitus pathogenesis.Journal of diabetes · 2018Article
- Effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia in the frequently sampled intravenous glucose tolerance test.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- MiR-206 is expressed in pancreatic islets and regulates glucokinase activity.American journal of physiology. Endocrinology and metabolism · 2016Article
- Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.Nature medicine · 2016Article
- Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in the GCKR Gene.The Journal of clinical endocrinology and metabolism · 2015Article
- Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein.Biochimica et biophysica acta · 2014Article
- Evolution- and structure-based computational strategy reveals the impact of deleterious missense mutations on MODY 2 (maturity-onset diabetes of the young, type 2).Theranostics · 2014Article
- FGF19 action in the brain induces insulin-independent glucose lowering.The Journal of clinical investigation · 2013Article
- Fructose in perspective.Nutrition & metabolism · 2013Article
- Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study.PloS one · 2013Article
- Comment on: Stefanovski et al. Estimating hepatic glucokinase activity using a simple model of lactate kinetics. Diabetes Care 2012;35:1015-1020.Diabetes care · 2012Article
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10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveGlucokinase (GCK) acts as a component of the "glucose sensor" in pancreatic β-cells and possibly in other tissues, including the brain. However, >99% of GCK in the body is located in the liver, where it serves as a "gatekeeper", determining the rate of hepatic glucose phosphorylation. Mutations in GCK are a cause of maturity-onset diabetes of the young (MODY), and GCKR, the regulator of GCK in the liver, is a diabetes susceptibility locus. In addition, several GCK activators are being studied as potential regulators of blood glucose. The ability to estimate liver GCK activity in vivo for genetic and pharmacologic studies may provide important physiologic insights into the regulation of hepatic glucose metabolism. RESEARCH DESIGN AND
methodsHere we introduce a simple, linear, two-compartment kinetic model that exploits lactate and glucose kinetics observed during the frequently sampled intravenous glucose tolerance test (FSIGT) to estimate liver GCK activity (K(GK)), glycolysis (K(12)), and whole body fractional lactate clearance (K(01)). RESULTS To test our working model of lactate, we used cross-sectional FSIGT data on 142 nondiabetic individuals chosen at random from the Finland-United States Investigation of NIDDM Genetics study cohort. Parameters K(GK), K(12), and K(01) were precisely estimated. Median model parameter estimates were consistent with previously published values.
conclusionsThis novel model of lactate kinetics extends the utility of the FSIGT protocol beyond whole-body glucose homeostasis by providing estimates for indices pertaining to hepatic glucose metabolism, including hepatic GCK activity and glycolysis rate.
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