ArticleThe American journal of clinical nutrition2012
Inverse association between brown adipose tissue activation and white adipose tissue accumulation in successfully treated pediatric malignancy.
Article in The American journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01517581 (Study on the Association Between Brown Adipose Tissue Activation and White Adipose Tissue Accumulation in Successfully Treated Pediatric Malignancy), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on the Association Between Brown Adipose Tissue Activation and White Adipose Tissue Accumulation in Successfully Treated Pediatric Malignancy
Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Effect of Propranolol on 18F-Fluorodeoxyglucose Uptake in Brown Adipose Tissue in Children and Young Adults with Neoplastic Diseases.Molecular imaging and biology · 2021Article
- Brown adipose tissue estimated with the magnetic resonance imaging fat fraction is associated with glucose metabolism in adolescents.Pediatric obesity · 2019Article
- Association of proton density fat fraction in adipose tissue with imaging-based and anthropometric obesity markers in adults.International journal of obesity (2005) · 2018Article
- Brown Adipose Tissue Energy Metabolism in Humans.Frontiers in endocrinology · 2018Review
- Association between supraclavicular brown adipose tissue composition at birth and adiposity gain from birth to 6 months of age.Pediatric research · 2017Article
- Maternal and cord blood adiponectin levels in relation to post-natal body size in infants in the first year of life: a prospective study.BMC pregnancy and childbirth · 2016Article
- Reducing Adiposity in a Critical Developmental Window Has Lasting Benefits in Mice.Endocrinology · 2016Article
- Developmental influences on circuits programming susceptibility to obesity.Frontiers in neuroendocrinology · 2015Review
- Human brown adipose tissue depots automatically segmented by positron emission tomography/computed tomography and registered magnetic resonance images.Journal of visualized experiments : JoVE · 2015Article
- Molecular imaging of brown adipose tissue in health and disease.European journal of nuclear medicine and molecular imaging · 2014Review
- Relevance of brown adipose tissue in infancy and adolescence.Pediatric research · 2013Review
- Characterization of human brown adipose tissue by chemical-shift water-fat MRI.AJR. American journal of roentgenology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAlthough the accumulation of white adipose tissue (WAT) is a risk factor for disease, brown adipose tissue (BAT) has been suggested to have a protective role against obesity.
objectiveWe studied whether changes in BAT were related to changes in the amounts of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in children treated for malignancy.
designWe examined the effect of BAT activity on weight, SAT, and VAT in 32 pediatric patients with cancer whose positron emission tomography-computed tomography (PET-CT) scans at diagnosis showed no BAT activity. Changes in weight, SAT, and VAT from diagnosis to remission for children with metabolically active BAT at disease-free follow-up (BAT+) were compared with those in children without visualized BAT when free of disease (BAT-).
resultsFollow-up PET-CT studies (4.7 ± 2.4 mo later) after successful treatment of the cancer showed BAT+ in 19 patients but no active BAT (BAT-) in 13 patients. BAT+ patients, in comparison with BAT- patients, gained significantly less weight (3.3 ± 6.6% compared with 11.0 ± 11.6%; P = 0.02) and had significantly less SAT (18.2 ± 26.5% compared with 67.4 ± 71.7%; P = 0.01) and VAT (22.6 ± 33.5% compared with 131.6 ± 171.8%; P = 0.01) during treatment. Multiple regression analysis indicated that the inverse relations between BAT activation and measures of weight, SAT, and VAT persisted even after age, glucocorticoid treatment, and the season when the PET-CT scans were obtained were accounted for.
conclusionThe activation of BAT in pediatric patients undergoing treatment of malignancy is associated with significantly less adipose accumulation. This trial was registered at clinicaltrials.gov as NCT01517581.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.