ArticleKidney international2012
Bone-specific alkaline phosphatase concentrations are less variable than those of parathyroid hormone in stable hemodialysis patients.
Article in Kidney international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Distinct longitudinal trajectories of alkaline phosphatase and parathyroid hormone at dialysis initiation predict mortality in incident hemodialysis patients.BMC nephrology · 2026Article
- Advances in noninvasive diagnosis of renal osteodystrophy.Renal failure · 2025Review
- Time-lapse HR-pQCT reliably assesses and monitors local bone turnover in patients with chronic kidney disease.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Update on the role of bone turnover markers in the diagnosis and management of osteoporosis: a consensus paper from The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), International Osteoporosis Foundation (IOF), and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Review
- Bone Turnover Markers: Basic Biology to Clinical Applications.Endocrine reviews · 2023Article
- Article
- Different Effects of Empagliflozin on Markers of Mineral-Bone Metabolism in Diabetic and Non-Diabetic Patients with Stage 3 Chronic Kidney Disease.Medicina (Kaunas, Lithuania) · 2021Article
- The Non-invasive Diagnosis of Bone Disorders in CKD.Calcified tissue international · 2021Review
- Association Between Alkaline Phosphatase and Muscle Mass, Strength, or Physical Performance in Patients on Maintenance Hemodialysis.Frontiers in medicine · 2021Article
- Effects of parathyroidectomy on blood bone markers and heart rate variability in patients with stage 5 chronic kidney disease.International urology and nephrology · 2018Article
- [Value of serum alkaline phosphatase for predicting 2-year fracture in patients with chronic kidney disease on dialysis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Alkaline phosphatase: a novel treatment target for cardiovascular disease in CKD.Nature reviews. Nephrology · 2017Review
- Biomarkers Predicting Bone Turnover in the Setting of CKD.Current osteoporosis reports · 2017Review
- Low-dose cholecalciferol supplementation and dual vitamin D therapy in haemodialysis patients.International urology and nephrology · 2015Article
- Calcitriol resistance in hemodialysis patients with secondary hyperparathyroidism.International urology and nephrology · 2014Review
- Recent advances in the noninvasive diagnosis of renal osteodystrophy.Kidney international · 2013Review
- Does PTH offer additive value to ALP measurement in assessing CKD-MBD?Peritoneal dialysis international : journal of the International Society for Peritoneal DialysisReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormalities of bone mineral metabolism and vascular calcification are prevalent in patients with kidney failure. Clinical management is based on biochemical targets, in particular parathyroid hormone (PTH) concentrations, but this has many limitations including high biological variation. A possible alternative is bone-specific alkaline phosphatase (ALP); therefore, we evaluated the biological variation of this marker in patients undergoing hemodialysis. Bone ALP was measured in non-fasting serum samples taken twice a week over a 6-week period in 22 stable hemodialysis patients and 12 healthy volunteers. The within-individual coefficients of variance were calculated and used to derive the critical difference required to be certain that an observed change was significant. The coefficient of variance for bone ALP was significantly higher in hemodialysis patients compared to healthy individuals. Seven samples were required to estimate the homeostatic set point of bone ALP, within 10%, in a hemodialysis patient. The concentration of serial bone ALP measurements would need to change by 36% between any two measurements before it can be considered a significant change. Since the biological variation of bone ALP is less than half that reported for PTH, our study provides further support for the use of bone ALP as an alternative marker of bone mineral metabolism in the setting of chronic kidney disease-mineral and bone disorder.
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