Trial reportNeuro-degenerative diseases2012
Tracking cognitive change over 24 weeks with longitudinal functional magnetic resonance imaging in Alzheimer's disease.
Trial report in Neuro-degenerative diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 53 citations in OpenAlex.
- Cerebellar Electrical Activity as a Marker for Predicting Brain Health and Disease: A Review.Brain sciences · 2026Review
- Systematic review of Free and Cued Selective Reminding Test with Immediate Recall (FCSRT-IR) studies: normative data, clinical validity, and correlations with biomarkers.Dementia & neuropsychologia · 2026Review
- Volumetric Changes in Cerebellar Transverse Zones: Age and Sex Effects in Health and Neurological Disorders.Human brain mapping · 2025Article
- Integrated cerebellar radiomic-network model for predicting mild cognitive impairment in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Shedding light on the brain: guidelines to address inconsistent data collection parameters in resting-state NIRS studies.Frontiers in neuroscience · 2025Article
- Aging, Neurodegenerative Disorders, and Cerebellum.International journal of molecular sciences · 2024Review
- Frequency-dependent alterations in functional connectivity in patients with Alzheimer's Disease spectrum disorders.Frontiers in aging neuroscience · 2024Article
- Alteration in temporal-cerebellar effective connectivity can effectively distinguish stable and progressive mild cognitive impairment.Frontiers in aging neuroscience · 2024Article
- Functional network connectivity patterns predicting the efficacy of repetitive transcranial magnetic stimulation in the spectrum of Alzheimer's disease.European radiology experimental · 2023Article
- Functional abnormalities of the cerebellum in vascular mild cognitive impairment.Brain imaging and behavior · 2023Article
- Functional abnormalities of the cerebellum in vascular mild cognitive impairment.Brain imaging and behavior · 2023Article
- Local Brain Network Alterations and Olfactory Impairment in Alzheimer's Disease: An fMRI and Graph-Based Study.Brain sciences · 2023Article
- The Effect of APOE ɛ4 on the Functional Connectivity in Frontoparietal Network in Hypertensive Patients.Brain sciences · 2022Article
- Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals.Nature communications · 2022Article
- The whole-brain voxel-based morphometry study in early stage of T2DM patients.Brain and behavior · 2022Article
- Differences Changes in Cerebellar Functional Connectivity Between Mild Cognitive Impairment and Alzheimer's Disease: A Seed-Based Approach.Frontiers in neurology · 2021Article
- Decreased Alpha Peak Frequency Is Linked to Episodic Memory Impairment in Pathological Aging.Frontiers in aging neuroscience · 2021Article
- Resistance, vulnerability and resilience: A review of the cognitive cerebellum in aging and neurodegenerative diseases.Neurobiology of learning and memory · 2020Review
- Dysfunction of Inferior Parietal Lobule During Sensory Gating in Patients With Amnestic Mild Cognitive Impairment.Frontiers in aging neuroscience · 2020Article
- Altered Intrinsic Brain Activity and Functional Connectivity Before and After Knee Arthroplasty in the Elderly: A Resting-State fMRI Study.Frontiers in neurology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies have revealed that functional magnetic resonance imaging (fMRI) blood oxygen level-dependent (BOLD) signal in specific brain regions correlates with cross-sectional performance on standardized clinical trial measures in Alzheimer's disease (AD); however, the relationship between longitudinal change in fMRI-BOLD signal and neuropsychological performance remains unknown.
objectiveTo identify changes in regional fMRI-BOLD activity that tracks change in neuropsychological performance in mild AD dementia over 6 months.
methodsTwenty-four subjects (mean age 71.6) with mild AD dementia (mean Mini Mental State Examination 21.7, Global Clinical Dementia Rating 1.0) on stable donepezil dosing participated in two task-related fMRI sessions consisting of a face-name paired associative encoding memory paradigm 24 weeks apart during a randomized placebo-controlled pharmaco-fMRI drug study. Regression analysis was used to identify regions where the change in fMRI activity for Novel > Repeated stimulus contrast was associated with the change scores on postscan memory tests and the Free and Cued Selective Reminding Test (FCSRT).
resultsCorrelations between changes in postscan memory accuracy and changes in fMRI activity were observed in regions including the angular gyrus, parahippocampal gyrus, inferior frontal gyrus and cerebellum. Correlations between changes in FCSRT-free recall and changes in fMRI were observed in regions including the inferior parietal lobule, precuneus, hippocampus and parahippocampal gyrus.
conclusionChanges in encoding-related fMRI activity in regions implicated in mnemonic networks correlated with changes in psychometric measures of episodic memory retrieval performed outside the scanner. These exploratory results support the potential of fMRI activity to track cognitive change and detect signals of short-term pharmacologic effect in early-phase AD studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.