ArticlePlastic and reconstructive surgery2012
Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible.
Article in Plastic and reconstructive surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Radioprotective role of amifostine on osteointegration of titanium implants in the tibia of rats.Journal of veterinary science · 2023Article
- Article
- Novel Formulation Strategy to Improve the Feasibility of Amifostine Administration.Pharmaceutical research · 2018Article
- Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis.Annals of plastic surgery · 2018Article
- Article
- Prophylactic administration of Amifostine protects vessel thickness in the setting of irradiated bone.Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2015Article
- Therapeutic effects of cytoprotective agent on breast reconstruction after breast cancer surgery.International journal of clinical and experimental medicine · 2015Article
- Amifostine reduces radiation-induced complications in a murine model of expander-based breast reconstruction.Plastic and reconstructive surgery · 2014Article
- Vascular analysis as a proxy for mechanostransduction response in an isogenic, irradiated murine model of mandibular distraction osteogenesis.Microvascular research · 2014Article
- Amifostine preserves osteocyte number and osteoid formation in fracture healing following radiotherapy.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2014Article
- Prophylactic amifostine preserves the biomechanical properties of irradiated bone in the murine mandible.Plastic and reconstructive surgery · 2014Article
- Protective effect of amifostine on high-dose methotrexate-induced small intestinal mucositis in mice.Digestive diseases and sciences · 2013Article
- Article
- Article
- Quantitative histologic evidence of amifostine-induced cytoprotection in an irradiated murine model of mandibular distraction osteogenesis.Plastic and reconstructive surgery · 2012Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRadiotherapy, a cornerstone of head and neck cancer treatment, causes substantial morbidity to normal adjoining bone. The authors assessed the radioprotective effect of amifostine therapy on the mineralization of the mandible using micro-computed tomography. They hypothesized that amifostine would safeguard the mandible from radiation-induced disruption of the mineralization process and the associated failure of new bone creation.
methodsMale Sprague-Dawley rats were randomized into three groups: control (n = 8), radiation therapy (n = 5), and amifostine (n = 8). Animals in the radiation therapy and amifostine groups underwent human bioequivalent radiation of 70 Gy in five fractions to the left hemimandible. Fifty-six days after irradiation, the hemimandibles were harvested for radiomorphometric analyses.
resultsAmifostine-treated animals exhibited less alopecia, mucositis, and weight loss in addition to increased cortical density in comparison with those treated with radiation therapy. Bone and tissue mineral densities showed statistically significant improvement in amifostine versus radiation therapy, and no difference was observed between amifostine and control groups. Detailed micro-computed tomographic analysis further demonstrated significant differences in the mineralization profile when comparing radiation therapy and amifostine. Amifostine maintained regions of lower mineralization consistent with the preservation of normal remodeling.
conclusionsThe authors have successfully demonstrated the ability of amifostine pretreatment to protect the natural mineralization profile of bone. This reflects the capacity of amifostine prophylaxis to safeguard the normal surrounding mandible from the impediments of collateral damage imposed by irradiation. Further study can correlate these findings with the potential use of amifostine to prevent the devastating associated morbidities of radiotherapy such as pathologic fractures and osteoradionecrosis.
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