ArticlePlastic and reconstructive surgery2012
Deferoxamine enhances the vascular response of bone regeneration in mandibular distraction osteogenesis.
Article in Plastic and reconstructive surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Fracture Fusion on Fast-Forward: Locally Administered Deferoxamine Significantly Enhances Fracture Healing in Animal Models: A Systematic Review and Meta-Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Pooled it
- Application of Deferoxamine in Tissue Regeneration Attributed to Promoted Angiogenesis.Molecules (Basel, Switzerland) · 2024Review
- Application of chemical factors for acceleration of consolidation phase of the distraction osteogenesis: a scoping review.Oral and maxillofacial surgery · 2023Article
- Core decompression combined with local DFO administration loaded on polylactic glycolic acid scaffolds for the treatment of osteonecrosis of the femoral head: a pilot study.BMC pharmacology & toxicology · 2023Article
- Scaffold Guided Bone Regeneration for the Treatment of Large Segmental Defects in Long Bones.Biomedicines · 2023Review
- Deferoxamine to Minimize Fibrosis During Radiation Therapy.Advances in wound care · 2022Article
- Overview of Physical and Pharmacological Therapy in Enhancing Bone Regeneration Formation During Distraction Osteogenesis.Frontiers in cell and developmental biology · 2022Review
- Hypoxia During the Consolidation Phase of Distraction Osteogenesis Promotes Bone Regeneration.Frontiers in physiology · 2022Article
- Experimental study of the effects of hypoxia simulator on osteointegration of titanium prosthesis in osteoporotic rats.BMC musculoskeletal disorders · 2021Article
- Exosomes secreted by endothelial progenitor cells accelerate bone regeneration during distraction osteogenesis by stimulating angiogenesis.Stem cell research & therapy · 2019Article
- Topical Deferoxamine Alleviates Skin Injury and Normalizes Atomic Force Microscopy Patterns Following Radiation in a Murine Breast Reconstruction Model.Annals of plastic surgery · 2018Article
- Deferoxamine but Not Dimethyloxalylglycine, L-Mimosine, or Cobalt Dichloride Can Interfere with the MTT Assay.BioMed research international · 2018Article
- Synergistic protection of bone vasculature and bone mass by desferrioxamine in osteoporotic mice.Molecular medicine reports · 2017Article
- Clinical Use of Deferoxamine in Distraction Osteogenesis of Irradiated Bone.The Journal of craniofacial surgery · 2016Article
- Translational treatment paradigm for managing non-unions secondary to radiation injury utilizing adipose derived stem cells and angiogenic therapy.Head & neck · 2016Article
- Article
- Current concepts of bone tissue engineering for craniofacial bone defect repair.Craniomaxillofacial trauma & reconstruction · 2015Review
- Deferoxamine enhances bone regeneration in mandibular distraction osteogenesis.Plastic and reconstructive surgery · 2014Article
- Article
- Stem cell therapy remediates reconstruction of the craniofacial skeleton after radiation therapy.Stem cells and development · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBone regeneration during distraction osteogenesis is intricately associated with an enhanced vascular response. Augmenting this response may offer considerable clinical advantages such as optimizing the quality of regenerate formation, decreasing lengthy consolidation periods, or increasing regenerate size and distance. Using deferoxamine, an angiogenic transcriptional activator, the authors posit that substantial increases in vascular volume beyond the normal response to mechanical distraction can be quantified with micro-computed tomography after vessel perfusion during mandibular distraction osteogenesis.
methodsTwo groups of Sprague-Dawley rats (n = 12) underwent external fixator placement, mandibular osteotomy, and 5.1-mm distraction. During distraction, the experimental group (n = 6) was treated with deferoxamine injections into the distraction gap. After consolidation, the animals were perfused and imaged with micro-computed tomography. Vascular radiomorphometrics were calculated and statistical comparison was conducted with the independent samples t test. A value of p ≤ 0.05 was considered statistically significant.
resultsA 40 percent statistically significant increase in the number of vessels (0.82 vessels/mm versus 1.15 vessels/mm; p < 0.012) and a complementary decrease in the space between vessels (1.18 mm versus 0.86 mm; p < 0.012) were calculated in the experimental regenerate when compared with controls. This robust increase in vascularity could also be readily observed with micro-computed tomographic image reconstruction. Gross examination revealed a denser regenerate in the deferoxamine-injected group that is clearly illustrated with Faxitron radiography.
conclusionThe authors' study quantifies the ability of deferoxamine to augment the vascular response of mandibular distraction osteogenesis and establishes correlations between this therapeutic enrichment and enhanced regenerate formation.
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Registered trials
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