Evidence map›Paper›PMID 22456316›Full record

ArticleTranscription

Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes.

Søren F Schmidt, Mette Jørgensen, Albin Sandelin, Susanne Mandrup

Open access · bronzeAbstract read
In one paragraph

Article in Transcription. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  3. Article
  4. PPARγ and the global map of adipogenesis and beyond.Trends in endocrinology and metabolism: TEM · 2014
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Søren F SchmidtDepartment of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Mette Jørgensen
Albin Sandelin
Susanne Mandrup
University of Southern Denmark · DK

Funding

Antiobesity Mechanism of CLA Isomer in Human AdipocytesR01DK063070 · NIDDK · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI MCINTOSH, MICHAEL K · 2002 to 2011
$2.7M
NIDDK NIH HHS 5R01-DK063070NIDDK NIH HHS R01 DK063070
6 · The paper itself

Abstract

Three recent studies have investigated interspecies retention of binding sites of peroxisome proliferator-activated receptor γ (PPARγ), the master regulator of adipocyte differention, between mouse and human adipocytes. Here we discuss the major findings and demonstrate that retention of binding events is highly context-dependent.

Indexed as

Chromatin Immunoprecipitation3T3-L1 CellsAdipocytesAnimalsBinding SitesCCAAT-Enhancer-Binding ProteinsHistonesHumansMicePPAR gammaProtein BindingCCAAT-Enhancer-Binding ProteinsHistonesPPAR gamma

Identifiers

PMID22456316
PMCPMC3679271
OpenAlexW1973808857

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.