ArticleBiophysical journal2012
Determining the Gaussian curvature modulus of lipid membranes in simulations.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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67 citing papers in PubMed.
- Prediction-Based Algorithms for Long-Range High-Speed Force Spectroscopy.Journal of molecular recognition : JMR · 2026Article
- Topological Approach to Measuring the Gaussian Curvature Modulus of Lipid Membranes in Simulation.Physical review letters · 2026Article
- From Molecular Insight to Mesoscale Membrane Remodeling: Curvature Generation by Arginine-Rich Cell-Penetrating Peptides.Small methods · 2026Article
- A tutorial for mesoscale computer simulations of lipid membranes: tether pulling, tubulation and fluctuations.Soft matter · 2025Review
- Article
- The lateral stress profile of fluid lipid membranes as revealed by the diffuse interface approach.Biophysical journal · 2025Article
- Topology and kinetic pathways of colloidosome assembly and disassembly.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dynamin-like Proteins Combine Mechano-constriction and Membrane Remodeling to Enable Two-Step Mitochondrial Fission via a "Snap-through" Instability.Journal of the American Chemical Society · 2025Article
- Protocell Dynamics: Modelling Growth and Division of Lipid Vesicles Driven by an Autocatalytic Reaction.Life (Basel, Switzerland) · 2025Article
- Membrane curvature sensing and symmetry breaking of the M2 proton channel from Influenza A.eLife · 2024Article
- The diffuse interface description of fluid lipid membranes captures key features of the hemifusion pathway and lateral stress profile.PNAS nexus · 2024Article
- Comparing Multifunctional Viral and Eukaryotic Proteins for Generating Scission Necks in Membranes.ACS nano · 2024Article
- Valency of Ligand-Receptor Binding from Pair Potentials.Journal of chemical theory and computation · 2024Article
- Multispherical shapes of vesicles with intramembrane domains.The European physical journal. E, Soft matter · 2024Article
- Experimental determination and mathematical modeling of standard shapes of forming autophagosomes.Nature communications · 2024Article
- The local variation of the Gaussian modulus enables different pathways for fluid lipid vesicle fusion.Scientific reports · 2024Article
- Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A Note on Vestigial Osmotic Pressure.Membranes · 2023Article
- Review
- Remodeling of the Plasma Membrane by Surface-Bound Protein Monomers and Oligomers: The Critical Role of Intrinsically Disordered Regions.The Journal of membrane biology · 2022Review
7 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Gaussian curvature modulus κ¯ of lipid bilayers likely contributes more than 100 kcal/mol to every cellular fission or fusion event. This huge impact on membrane remodeling energetics might be a factor that codetermines the complex lipid composition of biomembranes through tuning of κ¯. Yet, its value has been measured only for a handful of simple lipids, and no simulation has so far determined it better than a factor of two, rendering a systematic investigation of such enticing speculations impossible. Here we propose a highly accurate method to determine κ¯ in computer simulations. It relies on the interplay between curvature stress and edge tension of partially curved axisymmetric membrane disks and requires determining their closing probability. For a simplified lipid model we obtain κ¯ and its relation to the normal bending modulus κ for membranes differing both in stiffness and spontaneous lipid curvature. The elastic ratio κ¯/κ can be determined with a few percent statistical accuracy. Its value agrees with the scarce experimental data, and its change with spontaneous lipid curvature is compatible with theoretical expectations, thereby granting additional information on monolayer properties. We also show that an alternative determination of these elastic parameters based on moments of the lateral stress profile gives markedly different and unphysical values.
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